Fas配體(FasL)也稱為CD178，CD95配體或TNFSF6，是一種大小為40kDa的Ⅱ型跨膜糖蛋白，屬于TNF超家族的成員。FasL在活化的T細(xì)胞以及脾臟、睪丸和眼睛中表達(dá)。當(dāng)它與受體CD95（Fas）結(jié)合時(shí)，FasL誘導(dǎo)凋亡細(xì)胞死亡以維持外周耐受性。有些腫瘤過度表達(dá)FasL并誘導(dǎo)浸潤淋巴細(xì)胞凋亡，使腫瘤逃避免疫反應(yīng)的影響。CD178/CD95的相互作用也被認(rèn)為在CD8+細(xì)胞增殖和中性粒細(xì)胞外滲、趨化和存活中起作用。據(jù)報(bào)道，MFL3抗體可阻斷CD178/CD95誘導(dǎo)的細(xì)胞凋亡。
產(chǎn)品信息：
| 產(chǎn)品貨號 | BE0319 |
| 產(chǎn)品名稱 | InVivoMAb?anti-mouse?FasL?(CD178) |
| 規(guī)格 | 1mg,5mg,25mg,?50mg,?100mg |
| 克隆號 | MFL3 |
| 同種型(Isotype) | Armenian?Hamster?IgG |
| 免疫原(Immunogen) | BHK?cells?expressing?B6?mouse?FasL |
| 成分(Formulation) | PBS,?pH?7.0?? |
| Contains?no?stabilizers?or?preservatives |
| 內(nèi)毒素(Endotoxin) | <2EU/mg?(<0.002EU/μg) |
| Determined?by?LAL?gel?clotting?assay |
| 純度(Purity) | >95% |
| Determined?by?SDS-PAGE |
| 無菌(Sterility) | 0.2?μM?filtered |
| 生產(chǎn)(Production) | Purified?from?tissue?culture?supernatant?in?an?animal?free?facility |
| 純化(Purification) | Protein?A |
| 保存(Storage) | Undiluted?at?4°C?in?the?dark |
| 應(yīng)用(Reported?Applications) | in?vivo?FasL?blockade |
| In?vitro?FasL?blockade |
| Functional?assay |
| Immunohistochemistry?(paraffin) |
| Flow?Cytometry |
Application References:
Lakins, M. A., et al. (2018). 'Cancer-associated fibroblasts induce antigen-specific deletion of CD8 (+) T Cells to protect tumour cells.'?Nat Commun?9(1): 948.?PubMed
Lotti, R., et al. (2018). 'Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus.'?Front Immunol?9: 370.?PubMed
Bien, K., et al. (2017). 'Involvement of Fas/FasL pathway in the murine model of atopic dermatitis.'?Inflamm Res?66(8): 679-690.?PubMed
D'Aloia, M. M., et al. (2016). 'T lymphocytes engineered to express a CD16-chimeric antigen receptor redirect T-cell immune responses against immunoglobulin G-opsonized target cells.'?Cytotherapy?18(2): 278-290.?PubMed
Linkermann, A., et al. (2011). 'Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure.'?Kidney Int?79(2): 169-178.?PubMed
Kayagaki, N., et al. (1997). 'Polymorphism of murine Fas ligand that affects the biological activity.'?Proc Natl Acad Sci U S A?94(8): 3914-3919.?PubMed
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更多產(chǎn)品詳情，請點(diǎn)擊：https://bxcell.com/product/invivomab-anti-mouse-fasl-cd178/
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