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BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse VEGFR-2

2023-10-10
瀏覽次數(shù): 41

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse VEGFR-2

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產(chǎn)品描述:

DC101-CP132單克隆抗體是原始DC101單克隆的重組嵌合型抗體??勺兘Y(jié)構(gòu)域序列與原始DC101相同,但是恒定區(qū)序列已經(jīng)從大鼠IgG1變?yōu)樾∈驣gG2a。DC101-CP132單克隆抗體像原始大鼠IgG1抗體一樣,不包含F(xiàn)c突變。

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DC101-CP132單克隆抗體能與小鼠VEGFR-2(血管內(nèi)皮生長因子受體2)反應(yīng),VEGFR-2也稱為CD309、KDR和Flk-1。VEGFR-2是酪氨酸蛋白激酶家族的成員。當(dāng)結(jié)合到其配體血管內(nèi)皮生長因子時(shí)發(fā)揮生理作用,血管內(nèi)皮生長因子受體-2在血管發(fā)育和通透性中起關(guān)鍵作用。血管內(nèi)皮生長因子受體-2在成人心臟、肺、腎、腦和骨骼肌的內(nèi)皮細(xì)胞中高表達(dá),在其他組織中低表達(dá)。DC101單克隆抗體已被證明在體內(nèi)抑制VEGFR-2信號(hào)傳導(dǎo)。

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse VEGFR-2

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產(chǎn)品詳情:

產(chǎn)品名稱

RecombiMAb anti-mouse VEGFR-2

產(chǎn)品貨號(hào)

CP132

產(chǎn)品規(guī)格

1/5/25/50/100mg

反應(yīng)種屬

Mouse

克隆號(hào)

DC101-CP132

同種型

Mouse IgG2a(switched from rat IgG1)

免疫原

Mouse VEGFR-2-SEAPs soluble receptor

實(shí)驗(yàn)應(yīng)用

in vivo?blocking of VEGF/VEGFR-2 signaling*
in vitro?blocking of VEGFR signaling*
Western blot*
*Reported for the original rat IgG1 DC101 antibody

產(chǎn)品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無菌處理

0.2 μm filtration

純化方式

Protein G

分子量

150 kDa

小鼠病原檢測

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C,不能冷凍保存。

推薦同型對照

InVivoPlus mouse IgG2a isotype control, unknown specificity(貨號(hào)BP0085)

推薦抗體稀釋液

InVivoPure pH 7.0 Dilution Buffer(貨號(hào)IP0070)

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該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻(xiàn)引用:

應(yīng)用

文章

體內(nèi)VEGF/VEGFR-2信號(hào)阻斷

(in vivo blocking of VEGF/VEGFR-2 signaling)

1.?Ding, X., et al. (2015). 'Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8' Cancer Res 75(2): 330-343.

2.?Lee, H. J., et al. (2015). 'Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1alpha maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature' Int J Radiat Oncol Biol Phys 91(3): 621-630.

3.?Arulanandam, R., et al. (2015). 'VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection' Cancer Cell 28(2): 210-224.

4.?Kizhatil, K., et al. (2014). 'Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process' PLoS Biol 12(7): e1001912.

體內(nèi)VEGF/VEGFR-2信號(hào)阻斷,體外VEGFR信號(hào)阻斷

(in vivo blocking of VEGF/VEGFR-2 signaling, in vitro blocking of VEGFR signaling)

1.Larrayoz, M., et al. (2014). 'Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype' EMBO Mol Med 6(4): 539-550. ?

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