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BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

2023-09-01
瀏覽次數(shù): 172

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

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產(chǎn)品描述:

FGK4.5-CP133單克隆抗體是原始FGK4.5單克隆抗體的重組嵌合型抗體。可變結(jié)構(gòu)域序列與原始FGK4.5克隆號相同,但是恒定區(qū)序列已經(jīng)從大鼠IgG2a變?yōu)樾∈驣gG2a。FGK4.5-CP133抗體像原始大鼠IgG2a抗體一樣,不包含F(xiàn)c突變。

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FGK4.5-CP133單克隆抗體能與小鼠CD40(也稱為Bp50)反應(yīng)。CD40是一種48 kDa的I型跨膜糖蛋白,屬于腫瘤壞死因子受體(TNFR)超家族。CD40廣泛表達(dá)于抗原呈遞細(xì)胞(APCs),如樹突狀細(xì)胞、B細(xì)胞、巨噬細(xì)胞和單核細(xì)胞,以及非免疫內(nèi)皮細(xì)胞、基底上皮細(xì)胞和一系列腫瘤細(xì)胞上。CD40與其配體CD154結(jié)合后,作為共刺激分子激活B細(xì)胞、樹突狀細(xì)胞、單核細(xì)胞和其他APCs。CD40在B細(xì)胞活化、分化、增殖和免疫球蛋白同種型轉(zhuǎn)換以及樹突狀細(xì)胞成熟中起作用。激動性CD40單克隆抗體已被證明能激活A(yù)PCs并促進(jìn)抗腫瘤T細(xì)胞反應(yīng)。FGK4.5單克隆抗體是一種激動性抗體,已被證明能激活表達(dá)CD40的APC。FGK4.5單克隆抗體也可用于體外和體內(nèi)抑制CD40/CD154相互作用。

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40


產(chǎn)品詳情:

產(chǎn)品名稱

RecombiMAb anti-mouse CD40

產(chǎn)品貨號

CP133

產(chǎn)品規(guī)格

1/5/25/50/100mg

反應(yīng)種屬

Mouse

克隆號

FGK4.5-CP133

同種型

Mouse IgG2a(switched from rat IgG2a)

免疫原

Recombinant mouse CD40 fusion protein

實驗應(yīng)用

in vivo?CD40 activation*
in vitro?B cell stimulation/activation*
*Reported for the original rat IgG2a FGK4.5 antibody

產(chǎn)品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無菌處理

0.2 μm filtration

純化方式

Protein G

分子量

150 kDa

小鼠病原檢測

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C,不能冷凍保存。

推薦同型對照

InVivoPlus mouse IgG2a isotype control, unknown specificity(貨號BP0085)

推薦抗體稀釋液

InVivoPure pH 7.0 Dilution Buffer(貨號IP0070)

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?該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻(xiàn)引用:

應(yīng)用

文章

體內(nèi)CD40激活

(in vivo CD40 activation)

1.?Bauche, D., et al. (2018). 'LAG3(+) Regulatory T Cells Restrain?Interleukin-23-

Producing CX3CR1(+) Gut-Resident Macrophages?during Group 3 Innate Lymphoid?

Cell-Driven Colitis' Immunity 49(2): 342-352 e345.

2.?Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce?

antitumour T-cell immunity' Nature 521(7550): 99-104.

3.?Conde, P., et al. (2015). 'DC-SIGN(+) Macrophages Control the Induction of?

Transplantation Tolerance' Immunity 42(6): 1143-1158.

4.?Bartkowiak, T., et al. (2015). 'Unique potential of 4-1BB agonist antibody to promote?

durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine' Proc?

Natl Acad Sci U S A 112(38): E5290-5299.

體外B細(xì)胞刺激/激活

(in vitro B cell stimulation/activation)

1.?Xu, H., et al. (2015). 'Regulation of bifurcating B cell trajectories by mutual antagonism?

between transcription factors IRF4 and IRF8' Nat Immunol .

2.?Muppidi, J. R., et al. (2014). 'Loss of signalling via Galpha13 in germinal centre?

B-cell-derived lymphoma' Nature 516(7530): 254-258. ??

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BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

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