醛固酮（Aldosterone）是一種由腎上腺皮質(zhì)中的膽固醇合成的類固醇激素。醛固酮在腎臟和肝臟中代謝，并作為控制鈉鉀平衡的關(guān)鍵鹽皮質(zhì)激素發(fā)揮作用。腎上腺合成和釋放醛固酮主要受腎素-血管緊張素-醛固酮系統(tǒng)（RAAS）的調(diào)節(jié)，RAAS主要作用是調(diào)節(jié)和維持血壓、水電解質(zhì)平衡和維持人體內(nèi)環(huán)境穩(wěn)態(tài)。檢測血清醛固酮和血漿腎素在臨床上用于區(qū)分原發(fā)性和繼發(fā)性醛固酮增多癥。原發(fā)性醛固酮增多癥（醛固酮增多癥）的特征是腎素與醛固酮比率非常低，導(dǎo)致鈉滯留和血壓升高，通常是腎腺增生或腫瘤的結(jié)果。在繼發(fā)性醛固酮增多癥中，醛固酮的過量產(chǎn)生是由心力衰竭和腎動脈疾病等外部條件引起的。

ENZO Aldosterone ELISA kit是一種比色競爭法酶免疫檢測試劑盒，過夜?+ 1 小時可以得到檢測結(jié)果。

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●?高靈敏度，可檢測低至4.7 pg/ml的醛固酮

●?幾乎不與其他類固醇反應(yīng)

●?經(jīng)過人和嚙齒動物血清和血漿樣本驗(yàn)證和測試

●?超越半定量Western blot分析的全定量檢測

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產(chǎn)品信息

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部分產(chǎn)品引用文獻(xiàn)

1. A cardiac-null mutation of Prdm16 causes hypotension in mice with cardiac hypertrophy via increased nitric oxide synthase 1: J.O. Kang, et al.; PLoS One 17, e0267938 (2022)

2. Effects of amiloride on acetylcholine-dependent arterial vasodilation evolve over time in mice on a high salt diet: S.M. Mutchler, et al.; Physiol. Rep. 10, e15255 (2022)

3. Low-salt diet increases mRNA expression of aldosterone-regulated transporters in the intermediate portion of the endolymphatic sac: A. Matsubara, et al.; Pflugers Arch. (2022)

4. The microbiota-gut-kidney axis mediates host osmoregulation in a small desert mammal: Z. Nouri, et al.; NPJ Biofilms Microbiomes 8, 16 (2022)

5. The prognostic importance of the angiotensin II/angiotensin-(1–7) ratio in patients with SARS-CoV-2 infection: L.M. Amezcua-Guerra, et al.; Ther. Adv. Respir. Dis. 16, 17534666221122544 (2022)

6. Differential roles of VPS and RAAS in water homeostasis and a risk for kidney dysfunction in rats undergoing rapid fasting/dehydration with regular exercise: K. Hasegawa, et al.; Physiol. Rep. 9, e14670 (2021), Application(s): ELISA using rat plasma

7. Factors affecting the urinary aldosterone-to-creatinine ratio in healthy dogs and dogs with naturally occurring myxomatous mitral valve disease: A. Galizzi, et al.; BMC Vet. Res. 17, 15 (2021), Application(s): ELISA using dog urine

8. Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury: N. Ramkumar, et al.; Circ. Res. 129, 50 (2021), Application(s): Mouse urine and plasma

9. Metabolic syndrome during gestation and lactation: An important renal problem in dams. selenium renal clearance: F. Nogales, et al.; J. Trace Elem. Med. Biol. 64, 126709 (2021), Application(s): ELISA using rat serum

10. Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions: K. Miyauchi, et al.; EBioMedicine 64, 103209 (2021), Application(s): ELISA using rat plasma

11. Salt-Sensitivity of Volume and Blood Pressure in a Mouse with Globally Reduced ENaC γ Subunit Expression: E.C. Ray, et al.; Am. J. Physiol. Renal Physiol. 321, F705 (2021)

12. Sex-dependent Effects of Nephron Ift88 Disruption on Blood Pressure, Renal Function and Cystogenesis: C. Hu, et al.; J. Am. Soc. Nephrol. 32, 2210 (2021)

13. The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males: T. Tominaga, et al.; Antioxidants (Basel) 10, 866 (2021), Application(s): Aldosterone quantification on human plasma samples

14. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome: M. Punapart, et al.; Genes (Basel) 12, 1717 (2021)

15. Differences in Renal BMAL1 Contribution to Na + Homeostasis and Blood Pressure Control in Male and Female Mice: G.R. Crislip, et al.; Am. J. Physiol. Renal Physiol. 318, 1463 (2020)

16. Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion: A. Berthon, et al.; Hum. Mol. Genet. 2020, ddaa215 (2020)

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