精氨酸加壓素?(AVP) 是在大腦下丘腦中合成并儲(chǔ)存在垂體中的一種肽激素。AVP是一種抗利尿劑，可通過(guò)作用于腎小管以增加液體的重吸收和血容量來(lái)調(diào)節(jié)血壓。AVP升高和高血壓、心力衰竭相關(guān)。AVP通過(guò)與一組特定的包含七個(gè)跨膜結(jié)構(gòu)域的G蛋白偶聯(lián)受體(GPCR)結(jié)合而起作用，GPCR 分為三組：V1a (V1)、V1b (V3) 和 V2。V1b 受體刺激垂體前葉釋放促腎上腺皮質(zhì)激素 (ACTH)，但也可能參與下丘腦釋放促腎上腺皮質(zhì)激素釋放激素 (CRH)。V1b 受體通過(guò) Gq/11α亞基偶聯(lián)、激活磷脂酶 C 和通過(guò)磷酸肌醇第二信使釋放細(xì)胞內(nèi)Ca?2+發(fā)出信號(hào)。V1b受體過(guò)表達(dá)是促腎上腺皮質(zhì)激素分泌腺瘤的常見(jiàn)標(biāo)志物。腎臟集合管中的V2受體刺激腺苷酸環(huán)化酶活性，通過(guò)水通道蛋白通道調(diào)節(jié)水的重吸收。
● 高靈敏度，可檢測(cè)到低至2.84 pg/ml精氨酸加壓素
●?特異性高，與催產(chǎn)素幾乎不反應(yīng)
●?簡(jiǎn)單易用的液體顏色編碼試劑可減少錯(cuò)誤
●?超越半定量Western blot分析的全定量檢測(cè)
Enzo品牌Arg8-Vasopressin ELISA kit是一種比色競(jìng)爭(zhēng)法酶免疫檢測(cè)試劑盒，可在隔夜 + 1 小時(shí)內(nèi)得出結(jié)果。在 450 nm 處讀取吸光度。
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產(chǎn)品信息
產(chǎn)品貨號(hào) | ADI-900-017A |
產(chǎn)品名稱(chēng) | Arg8-Vasopressin ELISA kit（精氨酸加壓素ELISA試劑盒） |
規(guī)格 | 96 wells |
其他名稱(chēng) | AVP |
靈敏度 | 2.84 pg/ml |
檢測(cè)范圍 | 4.10-1,000 pg/ml |
檢測(cè)時(shí)間 | Overnight + 1 hour |
樣本種屬 | Species independent |
樣本類(lèi)型 | serum, plasma, and tissue culture media. |
保存溫度 | Store all components at +4°C, except standard at -20°C. |
試劑盒組分 | GxR IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, Standard, SA-HRP, TMB Substrate, Stop solution |
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部分產(chǎn)品文獻(xiàn)引用
1. Contrasting central and systemic effects of arginine-vasopressin on urinary marking behavior as a social signal in male mice: Y. Higuchi, et al.; Horm. Behav. 141, 105128 (2022)
2. Evaluating the neuropeptide-social cognition link in ageing: the mediating role of basic cognitive skills: R. Polk, et al.; Philos. Trans. R. Soc. Lond. B Biol. Sci. 29, 377 (2022)
3. Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71: E.V. Kozlova, et al.; Arch. Toxicol. 96, 335 (2022)
4. Renal function during sevoflurane or total intravenous propofol anaesthesia: a single-centre parallel randomised controlled study: S. Franzen, et al.; Br. J. Anaesth. 1289, 838 (2022)
5. Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells: M. Greenwood, et al.; Mol. Metab. 63, 101542 (2022)
6. Activation of Orexin 1 Receptors in the Paraventricular Nucleus Contributes to the Development of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation of Vasopressin: J. Bigalke, et al.; Front. Physiol. 12, 641331 (2021)
7. Autism-associated biomarkers: test–retest reliability and relationship to quantitative social trait variation in rhesus monkeys: O. Oztan, et al.; Mol. Autism 12, 13229 (2021)
8. Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism: M. Nakata, et al.; Nutrients 13, 4487 (2021)
9.Differential roles of VPS and RAAS in water homeostasis and a risk for kidney dysfunction in rats undergoing rapid fasting/dehydration with regular exercise: K. Hasegawa, et al.; Physiol. Rep. 9, e14670 (2021), Application(s): ELISA using rat plasma
10. Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure: Y. Funato, et al.; Nat. Commun. 12, 3683 (2021), Application(s): ELISA using mouse plasma
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Arg8-Vasopressin ELISA kit - ADI-900-017A - Enzo Life Sciences
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