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NOD1/2激動(dòng)劑及相關(guān)產(chǎn)品

2022-04-29
瀏覽次數(shù): 703

NOD1(又稱(chēng)CARD4)和NOD2(又稱(chēng)CARD15)是能感知細(xì)菌肽聚糖(PGN)成份的細(xì)胞內(nèi)模式識(shí)別受體。NOD1識(shí)別全部革蘭氏陰性菌和部分革蘭氏陽(yáng)性菌PGN成份中的iE-DAP,而NOD2則識(shí)別差不多全部細(xì)菌都帶有的MDP結(jié)構(gòu)。iE-DAP和MDP成份必須通過(guò)細(xì)菌侵入細(xì)胞或其它細(xì)胞物質(zhì)攝入方式進(jìn)入到細(xì)胞后才能被識(shí)別。識(shí)別配體后,NOD1和NOD2形成多聚體,通過(guò)RIP2激酶的絲氨酸/酪氨酸來(lái)傳遞訊號(hào)。激活后的RIP2可泛素化修飾NEMO/IKK?,從而引起NF-kB的活化和炎癥因子的釋放。


NOD1/2激動(dòng)劑相關(guān)產(chǎn)品:


PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

NOD1 Agonists

C12-iE-DAP

Acylated derivative of iE-DAP

TLR2 -/ TLR4 -

1 ng - 1 μg/ml

1 mg

tlrl-c12dap

C14-Tri-LAN-Gly???????????????? NEW

Meso?lanthionine tri-peptide (CL243)

TLR2 -/ TLR4 -

1 ng - 1 μg/ml

1 mg

tlrl-ctlg

iE-DAP

D-γ-Glu-mDAP

TLR2 -/ TLR4 -

1 - 100 μg/ml

5 mg

tlrl-dap

iE-Lys

iE-DAP negative control

TLR2 -/ TLR4 -

1 - 100 μg/ml

5 mg

tlrl-lys

Tri-DAP

L-Ala-γ-D-Glu-mDAP

TLR2 -/ TLR4 -

100 ng - 10 μg/ml

1 mg

tlrl-tdap

NOD2 Agonists

CL429

Pam2C-conjugated murabutide

TLR2 +/ TLR4 -

1 ng - 10 μg/ml

5 mg

tlrl-c429

CL429 VacciGrade?

TLR2/NOD2 agonist

VacciGrade?

20 -50 μg/mouse

5 mg

vac-c429

L18-MDP

Muramyldipeptide with a C18 fatty acid chain

TLR2 -/ TLR4 -

1 - 100 ng/ml

1 mg

tlrl-lmdp

MDP

Muramyldipeptide (L-D isoform, active)

TLR2 -/ TLR4 -

10 ng - 10 μg/ml

5 mg

tlrl-mdp

MDP control

Muramyldipeptide (D-D isoform, inactive)

TLR2 -/ TLR4 -

10 ng - 10 μg/ml

5 mg

tlrl-mdpc

M-TriLYS

Synthetic muramyl tripeptide

TLR2 -/ TLR4 -

100 ng - 10 μg/ml

1 mg

tlrl-mtl

Murabutide

Synthetic derivative of muramyldipeptide

TLR2 -/ TLR4 -

1 - 100 ng/ml

5 mg

tlrl-mbt

N-Glycolyl-MDP

N-glycolylated muramyldipeptide

TLR2 -/ TLR4 -

100 ng - 10 μg/ml

5 mg

tlrl-gmdp

NOD1/2 Agonists

M-TriDAP

MurNAc-L-Ala-γ-D-Glu-mDAP

TLR2 -/ TLR4 -

100 ng - 10 μg/ml

1 mg

tlrl-mtd

PGN-ECndi Ultrapure

Insoluble peptidoglycan from E. coli K12

TLR2 -/ TLR4 -

1 - 5 μg/ml

5 mg

tlrl-kipgn

PGN-ECndss Ultrapure

Soluble sonicated peptidoglycan from E. coli K12

TLR2 -/ TLR4 -

1 - 5 μg/ml

1 mg

tlrl-ksspgn

PGN-SAndi Ultrapure

Insoluble peptidoglycan from S. aureus

TLR2 -/ TLR4 -

1 - 5 μg/ml

5 mg

tlrl-sipgn


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