?吉西他濱加順鉑(GP)化療是鼻咽癌(NPC)的一種標(biāo)準(zhǔn)治療方式。然而,治療的機制尚不清楚。最近,中山大學(xué)科研團隊在期刊《Nature Medicine》(IF=82.9)上發(fā)表題為“The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment.”的文章,使用單細(xì)胞RNA測序,對首次治療和GP治療后的NPC樣本(n = 15對)的T細(xì)胞和B細(xì)胞受體測序匹配,結(jié)果顯示GP化療會激活先天樣B細(xì)胞(ILB)主導(dǎo)的抗腫瘤免疫反應(yīng)?;熣T發(fā)的DNA片段激活了STING, 增加干擾素依賴途徑在癌細(xì)胞中表達(dá)MHC Class I,并同時誘導(dǎo) ILB通過Toll樣受體9信號通路。對 germinal centers無效的化療,ILB通過ICOSL–ICOS軸進(jìn)一步擴大了follicular helper和helper type 1 T 細(xì)胞隨后增強三級淋巴器官樣結(jié)構(gòu)中的細(xì)胞毒性T細(xì)胞。ILB頻率是與3期臨床試驗中的接受GP化療的NPC患者(NCT01872962,n = 139)總體無病生存率呈正相關(guān)。ILB頻率可以作為GP和免疫療法聯(lián)合治療(n = 380)以下治療的NPC患者中作為有利結(jié)果的預(yù)測因子。該研究提供了GP化療后腫瘤免疫微環(huán)境的高分辨率地圖并發(fā)現(xiàn)B細(xì)胞為中心的抗腫瘤作用。研究還確定并驗證了在NPC以全科醫(yī)生為基礎(chǔ)的治療中ILB作為一個潛在的生物標(biāo)志物可以改善病人管理。
本文中使用了欣博盛Human IFN-β ELISA kit檢測了細(xì)胞培養(yǎng)上清中該蛋白的含量。
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1.文章題目:The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment.
期 ???刊:Nature Medicine(影響因子:82.9)
發(fā)表時間:6?June 2023
作 ???者:Lv J, Wei Y, Yin J H, et al.
作者單位:中山大學(xué)?
使用產(chǎn)品:Human IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37280275/
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2.文章題目:Inhibition of Phosphoglycerate dehydrogenase induces ferroptosis and overcomes enzalutamide resistance in castration-resistant prostate cancer cells.
期 ???刊:Drug Resistance Updates(影響因子:24.3)
發(fā)表時間:14?June 2023
作 ???者:Wang J, Zeng L, Wu N, et al.
作者單位:南方醫(yī)科大學(xué)?
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://www.sciencedirect.com/science/article/abs/pii/S1368764623000687
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3.文章題目:A Hierarchical 3D Graft Printed with Nanoink for Functional Craniofacial Bone Restoration.
期 ???刊:Advanced Functional Materials(影響因子:19)
發(fā)表時間:6?June 2023
作 ???者:Shi Y, Shi J, Sun Y, et al.
作者單位:浙江大學(xué)?
使用產(chǎn)品:Human BMP-2 ELISA kit
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202301099
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4.文章題目:Engineered Oxygen Factories Synergize with STING Agonist to Remodel Tumor Microenvironment for Cancer Immunotherapy.
期 ???刊:Advanced Functional Materials(影響因子:19)
發(fā)表時間:19 June 2023
作 ???者:Zhang X, Yang Y, Li J, et al.
作者單位:上海交通大學(xué)?
使用產(chǎn)品:Mouse IFN-γ and CXCL10 ELISA kits
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202300833
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5.文章題目:Innovative design of minimal invasive biodegradable poly (glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration.
期 ???刊:Nature Communications(影響因子:16.6)
發(fā)表時間:30?June 2023
作 ???者:Wang L, Jin K, Li N, et al.
作者單位:北京航空航天大學(xué)?
使用產(chǎn)品:Human SDF-1α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37391454/
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6.文章題目:A cell-free tissue-engineered tracheal substitute with sequential cytokine release maintained airway opening in a rabbit tracheal full circumferential defect model.?
期 ???刊:Biomaterials(影響因子:15.304)??
發(fā)表時間:17 June 2023
作 ???者:Liu Y, Zheng K, Meng Z, et al.
作者單位:空軍軍醫(yī)大學(xué)?
使用產(chǎn)品:Human TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37352607/
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7.文章題目:Self-Assembled Sulfated Hyaluronan Coating Modulates Transforming Growth Factor-Beta1 Penetration for Corneal Scarring Alleviation.
期 ???刊:ACS Applied Materials & Interfaces(影響因子:9.5)
發(fā)表時間:21?June 2023
作 ???者:Huang Y, Liu J, Sun X, et al.
作者單位:華南理工大學(xué)?
使用產(chǎn)品:Human TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37344377/
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8.文章題目:Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury.
期 ???刊:Journal of Neuroinflammation(影響因子:9.3)
發(fā)表時間:23?June 2023
作 ???者:Li J, Xu P, Hong Y, et al.
作者單位:南京大學(xué)?
使用產(chǎn)品:Mouse IL-1β and IL-18?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37353794/
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9.文章題目:Stapled peptide PROTAC induced significantly greater anti-PD-L1 effects than inhibitor in human cervical cancer cells.
期 ???刊:Frontiers in Immunology(影響因子:8.786)??
發(fā)表時間:1?June 2023
作 ???者:Shi Y Y, Wang A J, Liu X L, et al.
作者單位:武漢大學(xué)?
使用產(chǎn)品:Human TNF-α and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37325638/?
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10.文章題目:Long-term follow-up and exploration of the mechanism of stromal vascular fraction gel in chronic wounds.
期 ???刊:Stem Cell Research & Therapy(影響因子:8.079)??
發(fā)表時間:19?June 2023
作 ???者:Cai Y, Zhang F, Feng J, et al.
作者單位:遵義醫(yī)學(xué)院?
使用產(chǎn)品:Human bFGF, EGF, TGF-β1 and VEGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37337292/
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11.文章題目:NSAID–Au (I) Complexes Induce ROS-Driven DAMPs and Interpose Inflammation to Stimulate the Immune Response against Ovarian Cancer.
期 ???刊:Journal of Medicinal Chemistry(影響因子:7.3)
發(fā)表時間:8?June 2023
作 ???者:Xu Z, Lu Q, Shan M, et al.
作者單位:南京中醫(yī)藥大學(xué)?
使用產(chǎn)品:Mouse TNF-α and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37291753/
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12.文章題目:Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities.
期 ???刊:Acta Pharmacologica Sinica(影響因子:7.169)
發(fā)表時間:16?June 2023
作 ???者:Li H, Chen Y, Deng X, et al.
作者單位:沈陽藥科大學(xué)?
使用產(chǎn)品:Human IFN-γ ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37328649/
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13.文章題目:Luteolin Enhances Transepithelial Sodium Transport in the Lung Alveolar Model: Integrating Network Pharmacology and Mechanism Study.
期 ???刊:International Journal of Molecular Sciences(影響因子:6.208)
發(fā)表時間:18?June 2023
作 ???者:Chen L, Yu T, Zhai Y, et al.
作者單位:中國醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
樣本類型:肺泡灌洗液
https://www.mdpi.com/1422-0067/24/12/10122
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14.文章題目:TGF-β1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy.
期 ???刊:Cancer Immunology, Immunotherapy(影響因子:5.8)
發(fā)表時間:23?June 2023
作 ???者:Han L, Huang X, Zhao B, et al.
作者單位:中國藥科大學(xué)?
使用產(chǎn)品:Mouse IL-1β, TNF-α and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37351605/
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15.文章題目:Recombinant Phaseolus vulgaris phytohemagglutinin L-form expressed in the Bacillus brevis exerts in vitro and in vivo anti-tumor activity through potentiation of apoptosis and immunomodulation.?
期 ???刊:International Immunopharmacology(影響因子:5.714)?
發(fā)表時間:1?June?2023
作 ???者:Wang P, Hu J, Min S, et al. ?
作者單位:四川大學(xué)
使用產(chǎn)品:Mouse IFN-γ ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37269742/?
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16.文章題目:MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-κB signaling pathway.
期 ???刊:International Immunopharmacology(影響因子:5.714)??
發(fā)表時間:16?June?2023
作 ???者:Liu Z, Li Z, Yan G, et al.
作者單位:南方醫(yī)科大學(xué)
使用產(chǎn)品:Human IL-17A ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37331297/
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17.文章題目:Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway.
期 ???刊:International Immunopharmacology(影響因子:5.6)
發(fā)表時間:23 June 2023
作 ???者:Wu X, Xuan W, Yang X, et al.
作者單位:湖南省人民醫(yī)院?
使用產(chǎn)品:Mouse IL-1β ELISA kit
樣本類型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/37356123/
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18.文章題目:ZIM1 Combined with Hydrogel Inhibits Senescence of Primary PαS Cells during In Vitro Expansion.
期 ???刊:International Journal of Molecular Sciences(影響因子:5.6)
發(fā)表時間:5?June 2023
作 ???者:Tian Y, Hu M, Liu X, et al.
作者單位:北京大學(xué)口腔醫(yī)院?
使用產(chǎn)品:Mouse IL-8 ELISA kit
https://www.mdpi.com/1422-0067/24/11/9766
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19.文章題目:Klebsiella pneumoniae outer membrane vesicles induce strong IL-8 expression via NF-κB activation in normal pulmonary bronchial cells.
期 ???刊:International Immunopharmacology(影響因子:5.6)
發(fā)表時間:22?June 2023
作 ???者:Li P, Peng T, Xiang T, et al.
作者單位:南昌大學(xué)?
使用產(chǎn)品:Human IL-8 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37354781/
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20.文章題目:Inhibition of IL-4/STAT6/IRF4 signaling reduces the epithelial-mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps.
期 ???刊:International Immunopharmacology(影響因子:5.6)
發(fā)表時間:27?June 2023
作 ???者:Chen J, Chen S, Gong G, et al.
作者單位:華中科技大學(xué)同濟醫(yī)學(xué)院?
使用產(chǎn)品:Human TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37385124/
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21.文章題目:?Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo.
期 ???刊:International Immunopharmacology(影響因子:5.6)
發(fā)表時間:29?June 2023
作 ???者:Sun X, Hu X, Zhang Q, et al.
作者單位:華中農(nóng)業(yè)大學(xué)?
使用產(chǎn)品:Mouse TNF-α, IL-1β, and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37392567/
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22.文章題目:Microglia‐Mediated Neuroimmune Response Regulates Cardiac Remodeling After Myocardial Infarction.
期 ???刊:Journal of the American Heart Association(影響因子:5.4)
發(fā)表時間:15?June 2023
作 ???者:Wang M, Zhang J, Yin Z, et al.
作者單位:武漢大學(xué)人民醫(yī)院?
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37318008/
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23.文章題目:Protective effect and underlying mechanism of muscone on acute cerebral ischemia-reperfusion injury in rats.
期 ???刊:Journal of Ethnopharmacology(影響因子:5.4)
發(fā)表時間:25?June 2023
作 ???者:Zhang P, You S, Ding X, et al.
作者單位:廣東食品藥品職業(yè)學(xué)院藥學(xué)院?
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37364767/
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24.文章題目:Exploring the pharmacological mechanisms and key active ingredients of total flavonoids from Lamiophlomis rotata (Benth.) Kudo against rheumatoid arthritis based on multi-technology integrated network pharmacology.
期 ???刊:Journal of Ethnopharmacology(影響因子:5.4)
發(fā)表時間:27?June 2023
作 ???者:Zhan H, Chen R, Zhong M, et al. ?
作者單位:西南大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37385573/
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25.文章題目:DsbA‐L deletion attenuates LPS‐induced acute kidney injury by modulating macrophage polarization.
期 ???刊:European Journal of Immunology(影響因子:5.4)
發(fā)表時間:28?June 2023
作 ???者:Cui P, Chen C, Cui Y, et al.
作者單位:廣西大學(xué)?
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37379419/
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26.文章題目:Procoagulant effect of extracellular vesicles in patients after transcatheter aortic valve replacement or transcatheter aortic valve replacement with percutaneous coronary intervention.
期 ???刊:Journal of Thrombosis and Thrombolysis(影響因子:5.221)??
發(fā)表時間:7?June?2023
作 ???者:Chi H, Shao Y, Xie F, et al.
作者單位:青島大學(xué)?
使用產(chǎn)品:Human sICAM-1 and VCAM-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37284999/?
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27.文章題目:Gastroprotective Effects of the Aqueous Extract of Finger Citron Pickled Products against Ethanol-Induced Gastric Damage: In Vitro and In Vivo Studies.
期 ???刊:Foods(影響因子:5.2)
發(fā)表時間:13 June 2023
作 ???者:Chen X, Yang D, Wang Q, et al.
作者單位:華南農(nóng)業(yè)大學(xué)?
使用產(chǎn)品:Rat TNF-α, IL-6, IL-10 and IL-1β ELISA kits
https://www.mdpi.com/2304-8158/12/12/2355
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28.文章題目:Ciliated Cells Express a Novel Pattern of Brain-Derived Neurotrophic Factor in Allergic Rhinitis.
期 ???刊:Journal of Inflammation Research(影響因子:4.631)
發(fā)表時間:18?June 2023
作 ???者:Fang L, Li C H, Zhang Q, et al.
作者單位:山東大學(xué)?
使用產(chǎn)品:Mouse IgE ELISA kit
樣本類型:鼻灌洗液
https://www.tandfonline.com/doi/full/10.2147/JIR.S407368
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29.文章題目:HSP90-Dependent Upregulation of EZH2 Promotes Hypoxia/Reoxygenation-Induced Pyroptosis by Inhibiting miR-22 in Endothelial Cells.
期 ???刊:Journal of Inflammation Research(影響因子:4.631)
發(fā)表時間:19?June?2023
作 ???者:Deng P, Hu H.
作者單位:南京醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-1β and IL-18 ELISA kits
https://www.tandfonline.com/doi/full/10.2147/JIR.S403531
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30.文章題目:?An X-ray inactivated vaccine against Pseudomonas aeruginosa Keratitis in mice.
期 ???刊:Vaccine(影響因子:4.169)
發(fā)表時間:21?June 2023
作 ???者:Jiang B, Luo Y, Yan N, et al.
作者單位:四川大學(xué)?
使用產(chǎn)品:Mouse MIP-2, IL-10 and IL-1β(快速) ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37353454/
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31.文章題目:Two Novel Adenovirus Vectors Mediated Differential Antibody Responses via Interferon-α and Natural Killer Cells.
期 ???刊:Microbiology Spectrum(影響因子:3.7)
發(fā)表時間:22?June 2023
作 ???者:Zou P, Zhang P, Deng Q, et al.
作者單位:南方醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse IFN-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37347197/
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32.文章題目:?Isoliquiritigenin attenuates high glucose-induced proliferation, inflammation, and extracellular matrix deposition in glomerular mesangial cells by suppressing JAK2/STAT3 pathway.
期 ???刊:Naunyn-Schmiedeberg's Archives of Pharmacology(影響因子:3.6)
發(fā)表時間:27?June 2023
作 ???者:Zhang Z, Deng S, Shi Q.
作者單位:浙江工業(yè)大學(xué)?
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37368032/
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33.文章題目:A self-assembled nanoparticle vaccine based on pseudorabies virus glycoprotein D induces potent protective immunity against pseudorabies virus infection.
期 ???刊:Veterinary Microbiology(影響因子:3.246)
發(fā)表時間:5?June?2023
作 ???者:Ren X, Cao N, Tian L, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse and porcine IFN-γ, IL-2, TNF-α, IL-4, and IL-10?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37327558/
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34.文章題目:Immunogenic response of recombinant pseudorabies virus carrying B646L and B602L genes of African swine fever virus in mice.
期 ???刊:Veterinary Microbiology(影響因子:3.246)
發(fā)表時間:17?June 2023
作 ???者:Deng L, Gu S, Huang Y, et al.
作者單位:四川農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-4 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37348208/
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35.文章題目:Notoginsenoside R1 Protects against Diabetic Nephropathy through TXNIP-NLRP3 Signaling Pathway.
期 ???刊:Clinical Complementary Medicine and Pharmacology(影響因子:3)
發(fā)表時間:11?June 2023
作 ???者:Zhang C, Yuan R, Li S, et al.
作者單位:廣西中醫(yī)藥大學(xué)?
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://www.sciencedirect.com/science/article/pii/S2772371223000220
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36.文章題目:Protective effects of Zishen Huoxue recipe against neuronal injury in the neurovascular unit of rats with vascular dementia by interfering with inflammatory cascade-induced pyroptosis.
期 ???刊:Neuropeptides(影響因子:2.9)
發(fā)表時間:26?June 2023
作 ???者:Yao T, Xie L, Xie Y, et al.
作者單位:湖南省中西醫(yī)結(jié)合醫(yī)院?
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0143417923000392
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37.文章題目:Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury
期 ???刊:Clinical and Experimental Nephrology(影響因子:2.3)
發(fā)表時間:13 June 2023
作 ???者:Liu Y, Fang Q, Ming T, et al.
作者單位:武漢大學(xué)?
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37356123/
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38.文章題目:Geniposide protected against cerebral ischemic injury through the anti-inflammatory effect via the NF-κB signaling pathway.
期 ???刊:Translational Neuroscience(影響因子:2.1)
發(fā)表時間:9?June 2023
作 ???者:Sun Q, Zhang X, Fan J, et al.
作者單位:河北醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/37333874/
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39.文章題目:Fucoxanthin Alleviates Lipopolysaccharide-Induced Inflammation and Immunosuppression in RAW264. 7 Macrophages.
期 ???刊:Doklady Biochemistry and Biophysics(影響因子:0.8)
發(fā)表時間:20?June 2023
作 ???者:Wang Z, Wang M, Lin M, et al.
作者單位:遵義醫(yī)學(xué)院?
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37340299/
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