心肌梗死(MI)是世界范圍內(nèi)導(dǎo)致死亡和殘疾的主要原因之一,炎癥反應(yīng)在MI修復(fù)中起著關(guān)鍵作用。心肌梗死后,大量中性粒細胞、單核細胞和巨噬細胞在受損心肌募集,以誘導(dǎo)炎癥反應(yīng)。這些炎癥細胞的持續(xù)浸潤阻礙組織修復(fù),進而導(dǎo)致不良重塑和心功能受損。內(nèi)源性中性粒細胞凋亡的精確調(diào)節(jié)和誘導(dǎo)可能有利于促進再生。然而,中性粒細胞固有的存活/凋亡平衡是由復(fù)雜的信號因子網(wǎng)絡(luò)監(jiān)測的,誘導(dǎo)中性粒細胞凋亡的治療可能會干擾固有免疫反應(yīng)。而且,在原位精確地實現(xiàn)中性粒細胞凋亡的誘導(dǎo)是很困難的。因此,以凋亡中性粒細胞來克服復(fù)雜炎癥微環(huán)境的替代療法也許可以有效治療心肌梗死。
近期,第四軍醫(yī)大學(xué)金巖、劉世宇教授和西安交通大學(xué)陳鑫教授團隊在期刊《Bioactive Materials》上發(fā)表了題為“Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution”的文章,構(gòu)建了工程化中性粒細胞凋亡小體(eNABs)來模擬自然中性粒細胞凋亡,調(diào)節(jié)炎癥反應(yīng)并增強MI修復(fù)。eNABs是通過結(jié)合具有良好炎癥傾向性和免疫調(diào)節(jié)特性的自然中性粒細胞凋亡體膜和負載有5-氨基乙酰丙酸己酯鹽酸鹽(HAL)的介孔二氧化硅納米顆粒制備的。eNABs主動靶向巨噬細胞和組裝的HAL的同時啟動血紅素生物合成途徑,在細胞內(nèi)釋放后產(chǎn)生抗炎膽紅素,從而進一步增強抗炎作用。在體內(nèi)研究中,eNABs有效調(diào)節(jié)梗死區(qū)域的炎癥反應(yīng)以改善心功能。這項研究證明了一種有效的仿生構(gòu)建策略來調(diào)節(jié)巨噬細胞的功能以進行MI修復(fù)。
本文中使用了欣博盛大鼠TNF-α, IL-6, TGF-β and IL-10 ELISA試劑盒,檢測了大鼠巨噬細胞培養(yǎng)上清中細胞因子的含量。
1.文章題目:Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution.
期? ? 刊:Bioactive Materials(影響因子:14.593)
發(fā)表時間:27 August 2021
作? ? 者:Bao L, Dou G, Tian R, et al.
作者單位:第四軍醫(yī)大學(xué)
使用產(chǎn)品:Rat TNF-α, IL-6, TGF-β and IL-10 ELISA Kits? ?
https://www.sciencedirect.com/science/article/pii/S2452199X21003790
2.文章題目:Photodriven nanoreactor with a hydrogen-insulin double act repairs diabetic wounds through Nrf2 pathway activation.
期? ? 刊:Chemical Engineering Journal(影響因子:13.273)
發(fā)表時間:14 August 2021
作? ? 者:Zheng Y, Zhang Z, Wang T, et al.
作者單位:天津醫(yī)科大學(xué)
使用產(chǎn)品:Rat IL-6, IL-1β and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S1385894721033775
3.文章題目:MAGE-C3 promotes cancer metastasis by inducing epithelial-mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma.
期? ? 刊:Cancer Communications(影響因子:10.392)
發(fā)表時間:4 August 2021
作? ? 者:Wu Q, Zhang W, Wang Y, et al.
作者單位:北京大學(xué)腫瘤醫(yī)院
使用產(chǎn)品:Human IL-10 (H), TNF-α, IFN-γ and IL-1β ELISA Kits? ?
https://pubmed.ncbi.nlm.nih.gov/34347390/
4.文章題目:Synergy between Clinical Microenvironment Targeted Nanoplatform and Near-Infrared Light Irradiation for Managing Pseudomonas aeruginosa Infections.
期? ? 刊:ACS Applied Materials & Interfaces(影響因子:9.229)?
發(fā)表時間:16 August 2021
作? ? 者:Wei X, Li J, Zhang Y, et al.
作者單位:南開大學(xué)?
使用產(chǎn)品:Mouse IL-6, IL-1β and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34433249/
5.文章題目:Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1.
期? ? 刊:Pharmacological Research(影響因子:7.658)
發(fā)表時間:20 August 2021?
作? ? 者:Lv X, Zhou H, Hu K, et al.
作者單位:重慶醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits??
https://www.sciencedirect.com/science/article/abs/pii/S1043661821004229
6.文章題目:A Targeted Photosensitizer Mediated by Visible Light for Efficient Therapy of Bacterial Keratitis.
期? ? 刊:Biomacromolecules(影響因子:6.988)
發(fā)表時間:12 August 2021
作? ? 者:Yu C, Gao Y, Zhang Y, et al.
作者單位:南開大學(xué)
使用產(chǎn)品:Rat TNF-α and IL-6 ELISA Kits
樣本類型:眼角膜組織
https://pubmed.ncbi.nlm.nih.gov/34380309/
7.文章題目:Comparative study of structural properties and biological activities of polysaccharides extracted from Chroogomphus rutilus by four different approaches.
期? ? 刊:International Journal of Biological Macromolecules(影響因子:6.953)
發(fā)表時間:8 August 2021
作? ? 者:Zhao B, Zhao J, Lv M, et al.
作者單位:東北林業(yè)大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34371040/
8.文章題目:Purification and comparative study of bioactivities of a natural selenized polysaccharide from Ganoderma Lucidum mycelia.
期? ? 刊:International Journal of Biological Macromolecules(影響因子:6.953)
發(fā)表時間:31 August 2021
作? ? 者:Dong Z, Dong G, Lai F, et al.
作者單位:華南理工大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0141813021018638
9.文章題目:COX2 Enhances Neovascularization of Inflammatory Tenocytes Through the HIF-1α/VEGFA/PDGFB Pathway.
期? ? 刊:Frontiers in Cell and Developmental Biology(影響因子:6.684)
發(fā)表時間:4 August 2021
作? ? 者:Deng B, Xu P, Zhang B, et al.
作者單位:重慶大學(xué)
使用產(chǎn)品:Rat VEGF ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34422800/
10.文章題目:Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.
期? ? 刊:Acta Pharmacologica Sinica(影響因子:6.15)
發(fā)表時間:20 August 2021
作? ? 者:Li D, Yang C, Zhu J, et al.?
作者單位:成都中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6 and MCP-1 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34417576/
11.文章題目:Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice.
期? ? 刊:Pharmaceuticals(影響因子:5.863)
發(fā)表時間:21 August 2021
作? ? 者:Pan S, Hong F, Li L, et al.
作者單位:北京師范大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits? ??
https://pubmed.ncbi.nlm.nih.gov/34451919/
12.文章題目:Extraction kinetics, physicochemical properties and immunomodulatory activity of the novel continuous phase transition extraction of polysaccharides from Ganoderma lucidum.
期? ? 刊:Food & Function(影響因子:5.396)?
發(fā)表時間:11 August 2021
作? ? 者:Liu G, Zhang J, Hou T, et al.
作者單位:華南農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits
https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo02185k/unauth
13.文章題目:Isoforskolin, an adenylyl cyclase activator, attenuates cigarette smoke-induced COPD in rats.
期? ? 刊:Phytomedicine(影響因子:5.34)
發(fā)表時間:8 August 2021
作? ? 者:Xiao C, Cheng S, Lin H, et al.
作者單位:昆明醫(yī)科大學(xué)
使用產(chǎn)品:Rat CXCL1/KC (IL-8) ELISA Kit
https://www.sciencedirect.com/science/article/abs/pii/S0944711321002440
14.文章題目:Artesunate relieves acute kidney injury through inhibiting macrophagic Mincle-mediated necroptosis and inflammation to tubular epithelial cell.
期? ? 刊:Journal of Cellular and Molecular Medicine(影響因子:5.31)
發(fā)表時間:01 August 2021
作? ? 者:Lei X, Tan R, Jia J, et al.
作者單位:四川大學(xué)華西醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-1β ELISA Kits? ??
https://pubmed.ncbi.nlm.nih.gov/34337860/
15.文章題目:Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2.
期? ? 刊:PLoS Genetics(影響因子:5.917)
發(fā)表時間:30 August 2021
作? ? 者:Bao H, Sun Y, Yang N, et al.
作者單位:廈門大學(xué)
使用產(chǎn)品:HRP-conjuncted anti-rabbit secondary antibody? ?ANR02-2
https://pubmed.ncbi.nlm.nih.gov/34460816/
16.文章題目:LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM-1 in neurosyphilis.
期? ? 刊:Epigenomics(影響因子:4.778)?
發(fā)表時間:12 August 2021
作? ? 者:Liu W N, Wu K X, Wang X T, et al.
作者單位:廈門大學(xué)附屬中山醫(yī)院
使用產(chǎn)品:Human IFN-γ ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34382410/
17.文章題目:Notoginsenoside R1 alleviates the inflammation of osteoarthritis by activating the Nrf2/HO-1 signalling pathway in vitro and in vivo.
期? ? 刊:Journal of Functional Foods(影響因子:4.451)
發(fā)表時間:5 August 2021
作? ? 者:Chen M, Zhou S, Liu L, et al.
作者單位:武漢大學(xué)中南醫(yī)院
使用產(chǎn)品:Rat TNF-α and IL-6 ELISA Kits
https://www.sciencedirect.com/science/article/pii/S1756464621003157
18.文章題目:ATF3 inhibits arsenic-induced malignant transformation of human bronchial epithelial cells by attenuating inflammation.
期? ? 刊:Toxicology(影響因子:4.221)
發(fā)表時間:6 August 2021
作? ? 者:Shi Q, Hu B, Yang C, et al.
作者單位:浙江工業(yè)大學(xué)
使用產(chǎn)品:Human IL-6, IL-8 and TNFα ELISA Kits? ? ?
https://www.sciencedirect.com/science/article/abs/pii/S0300483X21002134
19.文章題目:B7 Family Molecule VSIG4 Regulates Intestinal Anti-Enterohemorrhagic Escherichia coli Immunity by Altering Gut Flora Diversity.
期? ? 刊:Microorganisms(影響因子:4.128)
發(fā)表時間:19 August 2021
作? ? 者:He Z, Li J, Gong S, et al.
作者單位:軍事醫(yī)學(xué)科學(xué)院微生物流行病研究所
使用產(chǎn)品:Mouse KC(IL-8) ELISA Kit? ??
https://pubmed.ncbi.nlm.nih.gov/34442848/
20.文章題目:Activation of CD200-CD200R1 Axis Attenuates Perioperative Neurocognitive Disorder Through Inhibition of Neuroinflammation in Mice.
期? ? 刊:Neurochemical Research(影響因子:3.996)?
發(fā)表時間:14 August 2021
作? ? 者:Ma D, Liu J, Wei C, et al.
作者單位:北京朝陽醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-4 and IL-10 ELISA Kits
樣本類型:海馬體
https://pubmed.ncbi.nlm.nih.gov/34392443/
21.文章題目:Pentagalloylglucose Reduces AGE-induced Inflammation by Activating Nrf2/HO-1 and Inhibiting the JAK2/STAT3 Pathway in Mesangial Cells.
期? ? 刊:Journal of Pharmacological Sciences(影響因子:3.337)
發(fā)表時間:26 August 2021
作? ? 者:Tong J, Fang J, Zhu T, et al.
作者單位:安徽大學(xué)?
使用產(chǎn)品:Mouse TNF-α ELISA Kit
https://www.sciencedirect.com/science/article/pii/S1347861321000815
22.文章題目:Cytokines and chemokines expression pattern in Herpes Simplex Virus Type-1 Encephalitis.
期? ? 刊:Neuroscience Letters(影響因子:3.046)
發(fā)表時間:12 August 2021
作? ? 者:Wang J, Cheng Y, Ma Y, et al.
作者單位:海南醫(yī)學(xué)院
使用產(chǎn)品:Mouse RANTES (CCL-5) and IL-6 ELISA Kits
樣本類型:大腦組織
https://pubmed.ncbi.nlm.nih.gov/34391869/
23.文章題目:N-acetyl-L-tryptophan attenuates hepatic ischemia-reperfusion injury via regulating TLR4/NLRP3 signaling pathway in rats.
期? ? 刊:PeerJ(影響因子:2.984)
發(fā)表時間:10 August 2021
作? ? 者:Pan Y, Yu S, Wang J, et al.
作者單位:濰坊醫(yī)學(xué)院
使用產(chǎn)品:Rat IL-1β ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34434653/
24.文章題目:hucMSC Conditioned Medium Ameliorate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Oxidative Stress and Inflammation via Nrf2/NF-κB Signaling Pathway.
期? ? 刊:Analytical Cellular Pathology(影響因子:2.916)
發(fā)表時間:14 August 2021
作? ? 者:Tang Y, Ding F, Wu C, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Human IL-6, IL-8 and TGF-β1 ELISA Kits?
https://pubmed.ncbi.nlm.nih.gov/34426780/
25.文章題目:MiR-20b-5p modulates inflammation, apoptosis and angiogenesis in severe acute pancreatitis through autophagy by targeting AKT3.
期? ? 刊:Autoimmunity(影響因子:2.815)?
發(fā)表時間:17 August 2021
作? ? 者:Tang G X, Yang M S, Xiang K M, et al.
作者單位:中南大學(xué)湘雅三醫(yī)院
使用產(chǎn)品:Rat IL-1β, TNF-α and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34402705/
26.文章題目:Mechanism by Which Tong Xie Yao Fang Heals the Intestinal Mucosa of Rats with Ulcerative Colitis through the Hippo Pathway.
期? ? 刊:Evidence-Based Complementary and Alternative Medicine(影響因子:2.629)
發(fā)表時間:31 August 2021
作? ? 者:You W, Xu Z, Di A, et al.
作者單位:青島大學(xué)附屬醫(yī)院
使用產(chǎn)品:Rat IL-6 ELISA Kit
樣本類型:結(jié)腸粘膜
https://pubmed.ncbi.nlm.nih.gov/34504536/
27.文章題目:Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells.
期? ? 刊:Reproduction, Fertility and Development(影響因子:2.31)
發(fā)表時間:17 August 2021
作? ? 者:Zhan X, Xie Y, Sun L, et al.
作者單位:浙江大學(xué)醫(yī)學(xué)院
使用產(chǎn)品:hCG ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34399087/
28.文章題目:Expression and Characterization of a Potent Long-Acting GLP-1 Receptor Like Agonist, Exendin-4-Fc.
期? ? 刊:International Journal of Peptide Research and Therapeutics(影響因子:1.931)
發(fā)表時間:11 August 2021
作? ? 者:Zhang W, Li M, Zan Y, et al.
作者單位:北京東方百泰生物科技股份有限公司
使用產(chǎn)品:Rat insulin ELISA Kit
https://link.springer.com/article/10.1007/s10989-021-10269-x
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