動脈粥樣硬化是許多心血管疾病中常見的病理現(xiàn)象。盡管目前的療法(包括他汀類藥物和絲氨酸蛋白酶PCSK9抑制劑)可以有效地將低密度脂蛋白(LDL)膽固醇水平降低到臨床指南推薦的水平,但心血管不良事件仍然頻繁發(fā)生。脂蛋白在動脈壁的內皮下滯留觸發(fā)了巨噬細胞的多種炎癥事件,是動脈粥樣硬化病理進展的主要原因。因此,調節(jié)炎癥是預防和治療動脈粥樣硬化及其并發(fā)癥的一種途徑。不幸的是,在控制斑塊炎癥的特異性和有效性方面的挑戰(zhàn)阻礙了動脈粥樣硬化治療的進展。最近,上海交通大學研究團隊在期刊《ACS nano》(IF=17.1)上發(fā)表題為“Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis”的文章,報道了一種NP介導的mRNA治療方法,以動脈粥樣硬化病變巨噬細胞為靶點,調節(jié)晚期動脈粥樣硬化病變中的炎癥,從而治療動脈粥樣硬化。證明了含有IL-10 mRNA的靶向NPs與M2樣巨噬細胞共定位,并在靜脈注射給Western diet(WD)喂養(yǎng)的Ldlr小鼠后誘導動脈粥樣硬化斑塊中IL-10的產(chǎn)生。此外,氧化應激和巨噬細胞凋亡減少證明損傷顯示出炎癥反應顯著減輕,導致脂質沉積減少,壞死面積減少,纖維帽厚度增加。這些結果表明,在晚期動脈粥樣硬化的臨床前模型中,將mRNA治療劑成功遞送至富含巨噬細胞的斑塊,表明這種靶向NP炎癥方法具有轉化為廣泛臨床應用的巨大潛力。
本文中使用了欣博盛Mouse IL-10, IL-1β和 IL-6 ELISA kits檢測了主動脈組織和血清樣本中目標蛋白的含量。
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1.文章題目:Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis.
期 ???刊:ACS nano(影響因子:17.1)
發(fā)表時間:5?September?2023
作 ???者:Gao M, Tang M, Ho W, et al.
作者單位:上海交通大學?
使用產(chǎn)品:Mouse IL-10, IL-1β, and IL-6 ELISA kits
樣本類型:主動脈組織
https://pubmed.ncbi.nlm.nih.gov/37669404/
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2.文章題目:Breaking Tumor Immunosuppressive Network by Regulating Multiple Nodes with Triadic Drug Delivery Nanoparticles.
期 ???刊:ACS nano(影響因子:17.1)
發(fā)表時間:10?September?2023
作 ???者:Yan W, Li Y, Zou Y, et al.
作者單位:中國科學院上海藥物研究所?
使用產(chǎn)品:Mouse IFN-γ and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37690028/
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3.文章題目:Self‐Assembled Virus‐like Particle Vaccines via Fluorophilic Interactions Enable Infection Mimicry and Immune Protection.
期 ???刊:Advanced Healthcare Materials(影響因子:10)
發(fā)表時間:13?September?2023
作 ???者:Xia Y, Liu K, Wang F, et al.
作者單位:揚州大學?
使用產(chǎn)品:Mouse IFN-γ, IL-17, and IL-4?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37703498/
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4.文章題目:Serine deficiency exacerbates psoriatic skin inflammation by regulating S‐adenosyl methionine‐dependent DNA methylation and NF‐κB signaling activation in keratinocytes.?
期 ???刊:Journal of the European Academy of Dermatology and Venereology(影響因子:9.2)?
發(fā)表時間:5?September?2023?
作 ???者:Meng Q, Liu Y, Yao L, et al. ?
作者單位:西安交通大學第二附屬醫(yī)院
使用產(chǎn)品:Mouse CXCL1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37669859/?
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5.文章題目:Mechanism of ozone alleviation of malignant ascites in hepatocellular carcinoma through the inhibition of neutrophil extracellular traps.
期 ???刊:PNAS nexus(影響因子:8.6)
發(fā)表時間:1?September?2023
作 ???者:Han F, Guo J, Mu M, et al.
作者單位:徐州醫(yī)科大學?
使用產(chǎn)品:Mouse IL-6, IFN-γ, TNF-α, MMP-9, and VEGF ELISA kits
樣本類型:腹水
https://pubmed.ncbi.nlm.nih.gov/37693209/
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6.文章題目:Programmed release of vascular endothelial growth factor and exosome from injectable chitosan nanofibrous microsphere-based PLGA-PEG-PLGA hydrogel for enhanced bone regeneration.
期 ???刊:International Journal of Biological Macromolecules(影響因子:8.2)??
發(fā)表時間:9?September?2023
作 ???者:Han S, Yang H, Ni X, et al.
作者單位:武漢大學?
使用產(chǎn)品:Human VEGF ELISA kit?
https://pubmed.ncbi.nlm.nih.gov/37673168/
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7.文章題目:Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis.
期 ???刊:International Journal of Biological Macromolecules(影響因子:8.2)
發(fā)表時間:20?September?2023
作 ???者:Liang Y, Xu X D, Xu X, et al.
作者單位:廣東醫(yī)科大學?
使用產(chǎn)品:Human TNF-α(Quick Test), IL-1β(Quick Test), IL-6(Quick Test), and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37734516/
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8.文章題目:Combination of irinotecan silicasome nanoparticles with radiation therapy sensitizes immunotherapy by modulating the activation of the cGAS/STING pathway for colorectal cancer.
期 ???刊:Materials Today Bio(影響因子:8.2)
發(fā)表時間:25?September?2023
作 ???者:Wang L, Zhang T, Zheng Y, et al. ?
作者單位:中國科學院杭州醫(yī)學研究所浙江腫瘤醫(yī)院?
使用產(chǎn)品:Human IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37779919/
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9.文章題目:Cornuside improves murine autoimmune hepatitis through inhibition of inflammatory responses.
期 ???刊:Phytomedicine(影響因子:7.9)
發(fā)表時間:9?September?2023
作 ???者:Wang L, Yan F, Zhang J, et al.
作者單位:山東大學?
使用產(chǎn)品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37716032/
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10.文章題目:FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1.
期 ???刊:Elife(影響因子:7.7)
發(fā)表時間:1?September?2023
作 ???者:Wang D, Zheng X, Chai L, et al.
作者單位:陜西師范大學?
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
樣本類型:前額皮質組織
https://pubmed.ncbi.nlm.nih.gov/37643469/
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11.文章題目:Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition.
期 ???刊:Stem Cell Research & Therapy(影響因子:7.5)
發(fā)表時間:19?September?2023
作 ???者:Wang Y, Jing L, Lei X, et al.
作者單位:第四軍醫(yī)大學?
使用產(chǎn)品:Mouse IL-1β and IL-18 ELISA kits
樣本類型:皮膚組織
https://pubmed.ncbi.nlm.nih.gov/37726853/
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12.文章題目:Design, Synthesis, and Activity Evaluation of Novel Dual-Target Inhibitors with Antifungal and Immunoregulatory Properties.
期 ???刊:Journal of Medicinal Chemistry(影響因子:7.3)
發(fā)表時間:13?September?2023
作 ???者:Sun B, Liu W, Wang Q, et al.
作者單位:聊城大學?
使用產(chǎn)品:Human PD-L1/B7-H1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37705322/
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13.文章題目:One-Step Purification of IgE Epitope-Specific Antibody Using Immunomagnetic Beads and Highly Sensitive Detection of Bovine β-Lactoglobulin for the Prediction of Milk Allergenicity in Foods.
期 ???刊:Journal of Agricultural and Food Chemistry(影響因子:6.1)
發(fā)表時間:7?September?2023
作 ???者:He S, Xiong M, Li L, et al.
作者單位:贛南醫(yī)學院
使用產(chǎn)品:HRP-streptavidin
https://pubmed.ncbi.nlm.nih.gov/37679308/
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14.文章題目:Identification of key phenolic compounds for alleviating gouty inflammation in edible chrysanthemums based on spectrum-effect relationship analyses.
期 ???刊:Food Chemistry: X(影響因子:6.1)
發(fā)表時間:22?September?2023
作 ???者:Huang Y, Tao M, Li R, et al.
作者單位:華中農(nóng)業(yè)大學?
使用產(chǎn)品:Human IL-1β and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S2590157523003401
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15.文章題目:Polo-like kinase 1 promotes pulmonary hypertension.
期 ???刊:Respiratory Research(影響因子:5.8)
發(fā)表時間:1?September?2023
作 ???者:Chen R, Wang H, Zheng C, et al.
作者單位:中國協(xié)和醫(yī)科大學?
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/37598171/
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16.文章題目:Efficacy and mechanism of Baicao Fuyanqing suppository on mixed vaginitis based on 16S rRNA and metabolomics.
期 ???刊:Frontiers in Cellular and Infection Microbiology(影響因子:5.7)
發(fā)表時間:14?September?2023
作 ???者:Wang Q, Wang P, Yuan M, et al.
作者單位:貴州醫(yī)科大學?
使用產(chǎn)品:Rat IL-1β, IL-2, and IgA ELISA kits
樣本類型:陰道灌洗液
https://pubmed.ncbi.nlm.nih.gov/37780858/
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17.文章題目:Polygalae Radix Oligosaccharide Esters May Relieve Depressive-like Behavior in Rats with Chronic Unpredictable Mild Stress via Modulation of Gut Microbiota.
期 ???刊:International Journal of Molecular Sciences(影響因子:5.6)
發(fā)表時間:9?September?2023
作 ???者:Chen Q, Jia T, Wu X, et al.
作者單位:首都醫(yī)科大學?
使用產(chǎn)品:Rat IL-6 ELISA kit
https://www.mdpi.com/1422-0067/24/18/13877
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18.文章題目:A CH2CH3 hinge region enhances the cytotoxicity of anti-CD5 CAR-T cells targeting T cell acute lymphoblastic leukemia.
期 ???刊:International Immunopharmacology(影響因子:5.6)??
發(fā)表時間:12?September?2023
作 ???者:Wu H, Yu Y, Zhao Y, et al.
作者單位:首都醫(yī)科大學
使用產(chǎn)品:Human IL-2, IFN-γ, IL-6, IL-15, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37690234/
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19.文章題目:IL-7 promotes CD19-directed CAR-T cells proliferation through miRNA-98-5p by targeting CDKN1A.
期 ???刊:International Immunopharmacology(影響因子:5.6)
發(fā)表時間:25?September?2023
作 ???者:Yang L R, Li L, Meng M Y, et al.
作者單位:昆明醫(yī)科大學?
使用產(chǎn)品:Human Granzyme B, perforin, TNF-α, IFN-γ, IL-2, IL-6 and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37757633/
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20.文章題目:HSPA13 modulates type I interferon antiviral pathway and NLRP3 inflammasome to restrict dengue virus infection in macrophages.
期 ???刊:International Immunopharmacology(影響因子:5.6)
發(fā)表時間:28?September?2023
作 ???者:Wang Q, Yang J, Li X, et al.
作者單位:佛山第四人民醫(yī)院?
使用產(chǎn)品:Human IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37776769/
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21.文章題目:PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway.
期 ???刊:International Immunopharmacology(影響因子:5.6)
發(fā)表時間:28?September?2023
作 ???者:Yu M, Tang W, Liang W, et al.
作者單位:華中科技大學同濟醫(yī)學院?
使用產(chǎn)品:Mouse IL-17, IL-4, and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37776771/
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22.文章題目:Integrative transcriptomic and metabolomic analysis in mice reveals the mechanism by which ginseng stem-leaf saponins enhance mucosal immunity induced by a porcine epidemic diarrhea virus vaccination.?
期 ???刊:Vaccine(影響因子:5.5)??
發(fā)表時間:12?September?2023
作 ???者:Su F, Xue Y, Ye S, et al.
作者單位:浙江省農(nóng)業(yè)科學院畜牧獸醫(yī)研究所?
使用產(chǎn)品:Mouse IFN-γ, IL-10 and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37704497/
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23.文章題目:Adenovirus-vectored PDCoV vaccines induce potent humoral and cellular immune responses in mice.
期 ???刊:Vaccine(影響因子:5.5)
發(fā)表時間:29?September?2023
作 ???者:Miao X, Zhang L, Zhou P, et al.
作者單位:中國農(nóng)業(yè)科學院蘭州獸醫(yī)研究所?
使用產(chǎn)品:Mouse IL-2, IL-4, IL-13, IFN-γ, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37777448/
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24.文章題目:Distribution profiles of phenolic compounds in a cultivar of wampee (Clausena lansium (Lour.) Skeels) fruits and in vitro anti-inflammatory activity.
期 ???刊:Journal of Ethnopharmacology(影響因子:5.4)
發(fā)表時間:11 September?2023
作 ???者:Zeng F, Chen M, Yang S, et al.
作者單位:中國熱帶農(nóng)業(yè)科學院農(nóng)產(chǎn)品加工研究所
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37704117/
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25.文章題目:BACH1 Loss Exerts Antitumor Effects on Mantle Cell Lymphoma Cells via Inducing a Tumor-Intrinsic Innate Immune Response and Cell-Cycle Arrest.
期 ???刊:Molecular Cancer Research(影響因子:5.2)
發(fā)表時間:27?September?2023
作 ???者:Li G, Feng M, Zhang Z, et al.
作者單位:中國醫(yī)學科學院和中國協(xié)和醫(yī)科大學醫(yī)學生物學研究所?
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37713314/
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26.文章題目:Polymer‐Protein Nanovaccine Synthesized via Reactive Self‐Assembly with Potential Application in Cancer Immunotherapy: Physicochemical And Biological Characterization In Vitro And in Vivo.
期 ???刊:Macromolecular Rapid Communications(影響因子:4.6)
發(fā)表時間:13?September?2023
作 ???者:Zhang M, Chen W, Ju Y, et al.
作者單位:中國醫(yī)學科學院?
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-2, and IL-4 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37708966/
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27.文章題目:Construction of a Collagen-like Protein Based on Elastin-like Polypeptide Fusion and Evaluation of Its Performance in Promoting Wound Healing.
期 ???刊:Molecules(影響因子:4.6)
發(fā)表時間:23?September?2023
作 ???者:Chen Y, Wu Y, Xiong F, et al.
作者單位:贛江中醫(yī)藥創(chuàng)新中心?
使用產(chǎn)品:Human Pro-Collagen I α1 ELISA kit (Quick Test)
https://www.mdpi.com/1420-3049/28/19/6773
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28.文章題目:Staphylococcus aureus Enterotoxin B Is a Cofactor of Food Allergy beyond a Superantigen.
期 ???刊:The Journal of Immunology(影響因子:4.4)??
發(fā)表時間:13?September?2023
作 ???者:Yuan J, Tong P, Wang Z, et al.
作者單位:南昌大學?
使用產(chǎn)品:Mouse IL-4 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37702994/
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29.文章題目:Lactobacillus fermentum Alleviates the Colorectal Inflammation Induced by Low-Dose Sub-Chronic Microcystin-LR Exposure.
期 ???刊:Toxins(影響因子:4.2)
發(fā)表時間:19?September?2023
作 ???者:Yang Y, Wen C, Zheng S, et al.
作者單位:南華大學?
使用產(chǎn)品:Mouse IL-6, TNF-α, IL-1β, and IL-10 ELISA kits
https://www.mdpi.com/2072-6651/15/9/579
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30.文章題目:Sinensetin Attenuated Macrophagic NLRP3 Inflammasomes Formation via SIRT1-NRF2 Signaling.
期 ???刊:ACS Omega(影響因子:4.1)
發(fā)表時間:6?September?2023
作 ???者:Lin L, Deng K, Gong Z, et al.
作者單位:廣州醫(yī)科大學?
使用產(chǎn)品:Mouse TNF-α ELISA kit(High Sensitivity)
https://pubs.acs.org/doi/full/10.1021/acsomega.3c03319
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31.文章題目:hMSCs treatment attenuates murine herpesvirus-68 (MHV-68) pneumonia through altering innate immune response via ROS/NLRP3 signaling pathway.
期 ???刊:Molecular Biomedicine(影響因子:4)
發(fā)表時間:4?September?2023
作 ???者:Qin A, Wang X, Fu J, et al.
作者單位:廣州醫(yī)科大學
使用產(chǎn)品:Mouse TNF-α, IFN-γ, IL-10, IL-1β, MCP-1, IL-6 and IFN-α ELISA kits
樣本類型:肺組織,肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/37704783/
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32.文章題目:CDK4/6i enhances the antitumor effect of PD1 antibody by promoting TLS formation in ovarian cancer.
期 ???刊:Heliyon(影響因子:4)
發(fā)表時間:13?September?2023
作 ???者:Feng W, Jiang D, Xu Y, et al.
作者單位:空軍軍醫(yī)大學?
使用產(chǎn)品:Mouse CCL21 ELISA kit
https://www.cell.com/heliyon/pdf/S2405-8440(23)06968-2.pdf
33.文章題目:Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking and in vivo experimental verification.?
期 ???刊:Pharmaceutical Biology(影響因子:3.8)??
發(fā)表時間:6?September?2023
作 ???者:Xin P, Xu X, Zhang H, et al.
作者單位:哈爾濱醫(yī)科大學?
使用產(chǎn)品:Rat TNF-α, IL-1β, IL-6, IL-10 and IL-17A ELISA kits
https://www.tandfonline.com/doi/full/10.1080/13880209.2023.2252854
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34.文章題目:Limonoids from the roots of Melia azedarach and their anti-inflammatory activity.
期 ???刊:Phytochemistry(影響因子:3.8)
發(fā)表時間:20?September?2023
作 ???者:Song M, Luo H J, Li Z W, et al.
作者單位:澳門大學?
使用產(chǎn)品:Human IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37739201/
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35.文章題目:Structural characterization, anti-tumor and immunomodulatory activity of intracellular polysaccharide from Armillaria luteo-virens.
期 ???刊:Carbohydrate Research(影響因子:3.1)
發(fā)表時間:16?September?2023
作 ???者:Li Z, Wang M, Yang Z.
作者單位:四川大學華西醫(yī)院?
使用產(chǎn)品:Mouse IL-2, IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37738818/
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36.文章題目:Natural killer cells modified with a Gpc3 aptamer enhance adoptive immunotherapy for hepatocellular carcinoma.
期 ???刊:Discover Oncology(影響因子:2.2)
發(fā)表時間:4?September?2023
作 ???者:Zheng Y, Lai Z, Wang B, et al.
作者單位:福建醫(yī)科大學?
使用產(chǎn)品:Human IFN-γ, TNF-α, perforin and IL-2 (High Sensitivity) ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37665421/
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37.文章題目:Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS-RA cells.
期 ???刊:Cellular and Molecular Biology(影響因子:1.6)
發(fā)表時間:1?September?2023
作 ???者:Zhao Z, Ma X, Dong S, et al.
作者單位:天津大學?
使用產(chǎn)品:Human IL-18 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37715399/
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38.文章題目:Amniotic membrane mesenchymal stromal cell-derived secretome in the treatment of acute ischemic stroke: A case report.
期 ???刊:World Journal of Clinical Cases(影響因子:1.1)
發(fā)表時間:26?September?2023
作 ???者:Lin F H, Yang Y X, Wang Y J, et al.
作者單位:赤峰學院?
使用產(chǎn)品:Human IL-6, TIMP-1, VEGF and HGF ELISA kits
https://www.wjgnet.com/2307-8960/full/v11/i27/6543.htm
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39.文章題目:Embelin enhances the osteogenic potential of LPS-induced periodontal ligament stem cells by activating AMPK and SIRT1.
期 ???刊:Tropical Journal of Pharmaceutical Research(影響因子:0.6)
發(fā)表時間:15?September?2023
作 ???者:Wang L, Wu W, Wei X.
作者單位:浙江中醫(yī)藥大學?
使用產(chǎn)品:Human TNF-α, IL-1β, IL-6, and MCP-1 ELISA kits
https://www.ajol.info/index.php/tjpr/article/view/254676
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