胰腺癌(Pancreatic cancer),特別是胰腺導管腺癌(PDAC),仍然是最致命的惡性腫瘤之一,在美國是癌癥相關死亡的第四大原因,在中國是癌癥導致死亡的第六大原因。雖然Abraxane和吉西他濱(GEM)的組合已被批準作為治療晚期胰腺導管癌(PDAC)的一線療法,但迄今為止,臨床抗腫瘤療效令人沮喪。最近,華中科技大學生命科學與技術學院納米醫(yī)學國家工程研究中心團隊在期刊《Nano Today》(IF=20.722)上發(fā)表題為“Hyperbaric oxygen regulates tumor mechanics and augments Abraxane and gemcitabine antitumor effects against pancreatic ductal adenocarcinoma by inhibiting cancer-associated fibroblasts.”的文章,探索高壓氧(HBO)療法來提高Abraxane和GEM對鼠PDAC Panc02腫瘤的抗腫瘤效果。該團隊在機理上揭示了HBO通過破壞缺氧顯著抑制癌相關成纖維細胞(CAFs)。由于CAFs是細胞外基質(ECM)成分的主要生產(chǎn)者,HBO有效地減少I型膠原和纖連蛋白,導致腫瘤和血管恢復正常化。因此,在腫瘤積累、滲透和細胞內(nèi)化方面,HBO增加了藥物輸送。此外,該研究團隊證明了HBO通過調(diào)節(jié)CAFs介導的腫瘤干細胞生態(tài)位來幫助Abraxane和GEM清除腫瘤干細胞。因此,HBO不僅通過抑制原發(fā)性腫瘤,而且更重要的是通過抑制Panc02腫瘤的轉移來增強Abraxane和GEM的抗腫瘤功效,并且副作用可以忽略不計。鑒于HBO、Abraxane和GEM在臨床實踐中的常規(guī)應用,它們的組合很容易轉化為臨床應用。
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本文中使用了欣博盛Mouse TGF-β1, VEGF ELISA kits檢測了腫瘤組織和血清樣本中的表達量。
1.文章題目:Hyperbaric oxygen regulates tumor mechanics and augments Abraxane and gemcitabine antitumor effects against pancreatic ductal adenocarcinoma by inhibiting cancer-associated fibroblasts.
期 ???刊:Nano Today(影響因子:20.722)
發(fā)表時間:16 March 2022
作 ???者:Wang X, Ye N, Xu C, et al.
作者單位:華中科技大學生命科學與技術學院納米醫(yī)學國家工程研究中心?
使用產(chǎn)品:Mouse TGF-β1, VEGF ELISA kits
樣本類型:胰腺癌腫瘤組織
https://www.sciencedirect.com/science/article/abs/pii/S1748013222000858
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2.文章題目:Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis.
期 ???刊:Advanced Science(影響因子:16.806)
發(fā)表時間:04 March 2022
作 ???者:Li Y, Li J, Li Z, et al.
作者單位:重慶大學生物工程學院?
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/35246964/
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3.文章題目:Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy.
期 ???刊:Bioactive Materials(影響因子:14.593)
發(fā)表時間:11?March 2022
作 ???者:Xie X, Feng Y, Zhang H, et al.
作者單位:電子科技大學生命科學與技術學院
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-6, IL-10, IL-12 ELISA kits
https://www.sciencedirect.com/science/article/pii/S2452199X22001244
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4.文章題目:An FPS-ZM1-encapsulated zeolitic imidazolate framework as a dual proangiogenic drug delivery system for diabetic wound healing.
期 ???刊:Nano Research(影響因子:8.897)
發(fā)表時間:4?March 2022
作 ???者:Sun Y, Bao B, Zhu Y, et al.
作者單位:上海交通大學附屬第六人民醫(yī)院?
使用產(chǎn)品:Mouse IL-6, TNF-α ELISA kits
https://link.springer.com/article/10.1007/s12274-022-4106-z
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5.文章題目:Exosomal microRNAs induce tumor-associated macrophages via PPARγ during tumor progression in SHH medulloblastoma.
期 ???刊:Cancer Letters(影響因子:8.679)
發(fā)表時間:8?March 2022
作 ???者:Zhu L, Yang Y, Li H, et al.
作者單位:北京大學醫(yī)學部?
使用產(chǎn)品:Mouse IL-10, TGF-β1, TNF-α, IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35304257/
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6.文章題目:Topical application of zein-silk sericin nanoparticles loaded with curcumin for improved therapy of dermatitis.
期 ???刊:Materials Today Chemistry(影響因子:8.301)
發(fā)表時間:3 March 2022
作 ???者:Zhu J J, Tang C H, Luo F C, et al.
作者單位:華南理工大學食品科學與工程學院?
使用產(chǎn)品:Human RANTES/CCL5, IL-6, CCL17/TARC?ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S2468519422000313
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7.文章題目:Mycobacterium tuberculosis Rv0309 Dampens the Inflammatory Response and Enhances Mycobacterial Survival.
期 ???刊:Frontiers in Immunology(影響因子:7.561)
發(fā)表時間:24 March?2022
作 ???者:Peng Y, Zhu X, Gao L, et al.
作者單位:華中農(nóng)業(yè)大學
使用產(chǎn)品:Mouse IL-6, TNF-α, IL-1βELISA kits
https://pubmed.ncbi.nlm.nih.gov/35281073/
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8.文章題目:Regulation of biomaterial implantation-induced fibrin deposition to immunological functions of dendritic cells.
期 ???刊:Materials Today Bio(影響因子:7.348)
發(fā)表時間:2 March 2022
作 ???者:Hu W, Wang Y, Chen J, et al.
作者單位:貴州醫(yī)科大學?
使用產(chǎn)品:Human IL-12 , IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35252832/
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9.文章題目:Enhancement of CD70-specific CAR T treatment by IFN-γ released from oHSV-1-infected glioblastoma.
期 ???刊:Cancer Immunology, Immunotherapy (影響因子:6.968)
發(fā)表時間:6?March 2022
作 ???者:Zhu G, Zhang J, Zhang Q, et al.
作者單位:首都醫(yī)科大學?
使用產(chǎn)品:Human IL-6, IL-8, TNF-α, TNF-β1, IL-4, IL-10, IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35249119/
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10.文章題目:Effects of selenylation modification on the antioxidative and immunoregulatory activities of polysaccharides from the pulp of Rose laevigata Michx fruit.
期 ???刊:International Journal of Biological Macromolecules(影響因子:6.953)
發(fā)表時間:1?March 2022
作 ???者:Zhan Q, Chen Y, Guo Y, et al.
作者單位:南京農(nóng)業(yè)大學?
使用產(chǎn)品:Mouse TNF-α, IL-6?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35240204/
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11.文章題目:Effects of UV/H2O2 degradation and step gradient ethanol precipitation on Sargassum fusiforme polysaccharides: Physicochemical characterization and protective effects against intestinal epithelial injury.
期 ???刊:Food Research International(影響因子:6.475)??
發(fā)表時間:2?March 2022
作 ???者:Yao W, Liu M, Chen X, et al.
作者單位:華南理工大學食品科學與工程學院?
使用產(chǎn)品:Rat TNF-α ELISA Kit
https://www.sciencedirect.com/science/article/abs/pii/S0963996922001508
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12.文章題目:JAK2/STAT3 pathway regulates microglia polarization involved in hippocampal inflammatory damage due to acute paraquat exposure.?
期 ???刊:Ecotoxicology and Environmental Safety(影響因子:6.291)??
發(fā)表時間:3?March 2022
作 ???者:Fan Z, Zhang W, Cao Q, et al.
作者單位:河北醫(yī)科大學?
使用產(chǎn)品:Mouse TNF-α , IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35248926/
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13.文章題目:Intramuscular injection of sotagliflozin promotes neovascularization in diabetic mice through enhancing skeletal muscle cells paracrine function.
期 ???刊:Acta Pharmacologica Sinica(影響因子:6.15)
發(fā)表時間:15?March 2022
作 ???者:Luo L, Han J, Wu S, et al.
作者單位:重慶大學生物工程學院?
使用產(chǎn)品:Mouse VEGF, PDGF-BB ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35292769/
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14.文章題目:Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo.
期 ???刊:Journal of Environmental Sciences(影響因子:5.565)
發(fā)表時間:18?March 2022
作 ???者:Ma J, Xie Y, Xu Y, et al.
作者單位:華中科技大學同濟醫(yī)學院?
使用產(chǎn)品:Mouse TNF-α,IL-6?ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S1001074222001346
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15.文章題目:Osteoinductive hybrid hydrogel membranes for in situ bone regeneration in hyperglycemia.
期 ???刊:Colloids and Surfaces B: Biointerfaces(影響因子:5.268)?
發(fā)表時間:11?March 2022
作 ???者:Liu Y, Wang J, Jiang M, et al. ?
作者單位:華東理工大學
使用產(chǎn)品:Mouse VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35287069/
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16.文章題目:Blocking GSDME-mediated pyroptosis in renal tubular epithelial cells alleviates disease activity in lupus mice.?
期 ???刊:?Cell Death Discovery(影響因子:5.241)??
發(fā)表時間:12?March 2022
作 ???者:Luo G, He Y, Yang F, et al.
作者單位:南方醫(yī)科大學?
使用產(chǎn)品:Mouse IL-6, TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35279675/
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17.文章題目:A pH-Driven Indomethacin-loaded Nanomedicine for Effective Rheumatoid Arthritis Therapy by Combining with Photothermal Therapy.
期 ???刊:Journal of Drug Targeting(影響因子:5.121)
發(fā)表時間:15?March 2022
作 ???者:Hu S, Lin Y, Tong C, et al.
作者單位:湖南中醫(yī)藥大學?
使用產(chǎn)品:Mouse TNF-α, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35282742/
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18.文章題目:A bioactive gypenoside (GP-14) alleviates neuroinflammation and blood brain barrier (BBB) disruption by inhibiting the NF-κB signaling pathway in a mouse high-altitude cerebral edema (HACE) model.
期 ???刊:International Immunopharmacology(影響因子:4.932)
發(fā)表時間:14 March 2022
作 ???者:Geng Y, Yang J, Cheng X, et al.
作者單位:北京基礎醫(yī)學研究所?
使用產(chǎn)品:Mouse VEGF-A, PDGF-BB ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35299003/
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19.文章題目:Construction and Biocompatibility Evaluation of Fibroin/Sericin-Based Scaffolds.
期 ???刊:?ACS Biomaterials Science & Engineering(影響因子:4.749)??
發(fā)表時間:1?March 2022
作 ???者:Fu Z, Li W, Wei J, et al.
作者單位:南通大學神經(jīng)再生聯(lián)合創(chuàng)新中心?
使用產(chǎn)品:Mouse IgG ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35230824/
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20.文章題目:Study on the characterization of polysaccharide from Tuber sinense and its desensitization effect to β-lactoglobulin in vivo.
期 ???刊:Journal of Functional Foods(影響因子:4.451)??
發(fā)表時間:6 March 2022
作 ???者:Li M, Zhang X, Zhang Y, et al.
作者單位:成都中醫(yī)藥大學藥學院?
使用產(chǎn)品:Mouse IgE, IL-4, IL-10, IL-13, IL-22 ELISA kits
https://www.sciencedirect.com/science/article/pii/S1756464622000986
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21.文章題目:?Effectiveness and immune responses of focused ultrasound ablation for cervical intraepithelial neoplasia.
期 ???刊:International Journal of Hyperthermia(影響因子:3.914)
發(fā)表時間:21?March 2022
作 ???者:Zeng H, Liu M, Xiao L, et al.
作者單位:重慶醫(yī)科大學?
使用產(chǎn)品:Human IgA, IL-10 ELISA kits
樣本類型:陰道灌洗液
https://pubmed.ncbi.nlm.nih.gov/35313793/
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22.文章題目:Ski regulates the inflammatory response of reactive astrocytes induced by oxygen glucose deprivation/reoxygenation (OGD/R) through the NF-κB pathway.
期 ???刊:Neuroscience(影響因子:3.59)
發(fā)表時間:23?March 2022
作 ???者:Liao H Y, Ran R, Da C M, et al.
作者單位:蘭州大學第二臨床醫(yī)學院?
使用產(chǎn)品:Rat IL-1β, TNF-α, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35339646/
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23.文章題目:Amygdalin protects against acetaminophen-induced acute liver failure by reducing inflammatory response and inhibiting hepatocyte death.
期 ???刊:Biochemical and Biophysical Research Communications(影響因子:3.575)
發(fā)表時間:5 March 2022
作 ???者:Congcong Z, Jiacheng L, Chao Z, et al.
作者單位:上海中醫(yī)藥大學附屬曙光醫(yī)院
使用產(chǎn)品:Mouse IL-6, TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35259588/
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24.文章題目:?Fibroblast growth factor 9 attenuates sepsis-induced fulminant hepatitis in mice.
期 ???刊:Amino Acids(影響因子:3.52)
發(fā)表時間:18?March?2022
作 ???者:Li A, Li X M, Song C G, et al.
作者單位:廣東醫(yī)科大學附屬醫(yī)院?
使用產(chǎn)品:Mouse TNF-α, IL-6, IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35304640/
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25.文章題目:Serum‐derived exosomes from SD rats induce inflammation in macrophages through the mTOR pathway.
期 ???刊:?Journal of Applied Toxicology(影響因子:3.446)
發(fā)表時間:15?March 2022
作 ???者:Wang Y, Liu Y, Sun Z, et al.
作者單位:南華大學?
使用產(chǎn)品:Rat IL-10, TNF-α, IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35289950/
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26.文章題目:Respiratory MUC5B disproportion is involved in severe community-acquired pneumonia.
期 ???刊:BMC Pulmonary Medicine(影響因子:3.317)
發(fā)表時間:15?March 2022
作 ???者:Fan L, Lu Y, Wang Y, et al.
作者單位:南京醫(yī)科大學?
使用產(chǎn)品:Human IL-6, IL-10,?IFN-γ, IL-13, IL-17?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35292003/
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27.文章題目:microRNA‐126 inhibits vascular cell adhesion molecule‐1 and interleukin‐1beta in human dental pulp cells.
期 ???刊:Journal of Clinical Laboratory Analysis(影響因子:2.352)
發(fā)表時間:25?March 2022
作 ???者:Jiang L, Krongbaramee T, Lin X, et al.
作者單位:上海交通大學醫(yī)學院?
使用產(chǎn)品:Human IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35334501/
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28.文章題目:The toxicity of perfluorodecanoic acid is mainly manifested as a deflected immune function.
期 ???刊:Molecular Biology Reports(影響因子:2.316)??
發(fā)表時間:2?March 2022
作 ???者:Li K, Zhao Q, Fan Z, et al.?
作者單位:山東大學齊魯醫(yī)學院基礎醫(yī)學院
使用產(chǎn)品:Mouse IL-18 ELISA kit
樣本類型:肝組織
https://pubmed.ncbi.nlm.nih.gov/35233679/
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