產(chǎn)品名稱:Bortezomib
產(chǎn)品描述:蛋白酶體抑制劑
產(chǎn)品貨號:SIH-328
純度:>98%
CAS號:179324-69-7
分子式:C19H25BN4O4
分子量:384.2
產(chǎn)品特性
儲存溫度:-20oC
運輸溫度:常溫運輸
產(chǎn)品類型:抑制劑
溶解性:溶解于DMSO (50mg/mL), 乙醇 (35mg/mL )
來源:合成的
性狀:白色粉末
SMILES:B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
InChIKey:GXJABQQUPOEUTA-RDJZCZTQSA-N
安全術(shù)語:安全級別: 注意: 物質(zhì)尚未充分測試. 安全術(shù)語: S22 -不要吸入粉塵 S36/37/39 - 穿戴適當(dāng)?shù)姆雷o服、手套和眼睛/面部保護 S24/25- 避免皮膚和眼睛接觸
引用該產(chǎn)品:Bortezomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-328)
生物學(xué)特性
別名:Bortezomib, 保特佐米, B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; Radiciol
研究領(lǐng)域:癌癥, 細胞凋亡, 腫瘤生長抑制劑, 蛋白酶體抑制劑
PubChem ID:387447
科研背景:Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis. Reversible. Cell permeable.
參考資料:1. Adams J., et al. (1999) Cancer Res. 59: 2615. 2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835.
訂購詳情
文獻引用
Extracellular vesicles drived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts.
Dieude, M. et al. (2019) Am J Transpl 20(3):726-738.
PubMed ID: 31729155 應(yīng)用范圍: In vitro inhibition
The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection
Dieude, M. et al. (2019) Sci Transl Med 7(318)
PubMed ID: 26676607 應(yīng)用范圍: In vitro inhibition
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