Stressmarq公司生產(chǎn)研發(fā)的Alpha Synuclein 蛋白是一款比較熱銷的產(chǎn)品，該產(chǎn)品貨號為SPR-316。下文是對該產(chǎn)品的具體介紹，如需購買該產(chǎn)品，請聯(lián)系一級代理商欣博盛生物。

產(chǎn)品名稱：Alpha Synuclein 蛋白

產(chǎn)品描述：活性重組人Alpha Synuclein 蛋白單體 (2型)

應用范圍：WB, SDS-PAGE, In vivo assay, In vitro assay

濃度：各批次不同，請詳見說明書

標記物：無標簽

性質(zhì)：重組

來源物種：人

表達系統(tǒng)：大腸桿菌 (E. coli)

氨基酸序列：MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

純度：>95%

蛋白長度：全長蛋白

Full Biological Activity:硫磺素 T 曲線顯示當2型單體 (SPR-316) 被PFFs引起聚集時形成的 β-sheet 聚集要比1型單體 (SPR-321) 少.

儲存緩沖液：PBS pH 7.4

儲存溫度：-80oC

運輸溫度：干冰. 運輸: 該產(chǎn)品會與其他同訂單產(chǎn)品分開發(fā)貨.

純化方式：離子交換層析純化

Protein Size：分子量約為14.46kDa.

引用該產(chǎn)品：Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences, Canada, Cat # SPR-316B)

分析證書：該蛋白已經(jīng)通過SDS-PAGE檢測證明純度為95%.

其他相關信息：經(jīng) LAL assay檢測，內(nèi)毒素低于1EU/μg .

別名：Alpha Synuclein Protein, AlphaSyn Protein, NACP Protein, Non A4 component of amyloid Protein, PARK1 Protein, PARK4 Protein, SNCA Protein, SYN Protein, Parkison disease familial 1 Protein

研究領域：神經(jīng)纖維纏結(jié)&Tau, 突觸核蛋白, 神經(jīng)生物學, 神經(jīng)衰退疾病, 帕金森氏病, 阿爾茨海默病

細胞定位：細胞核, 細胞質(zhì), 膜

Accession Number ：NP_000336.1

GeneID：6622

Swiss Prot：P37840

科研背景：

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

參考資料：

1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).

2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.

3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.

4. Kokhan V.S., Afanasyeva M.A., Van’kin G. (2012) Behav. Brain. Res. 231(1): 226-230.

5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.

6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

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