目前認為 , 各種腦損傷 ( 腦缺氧、腦外傷 ) 的繼發(fā)性損傷或稱二次腦損傷 (secondary injury) 因素是造成腦損害發(fā)生、發(fā)展的重要原因。
這些因素涉及：腦缺氧、鈣離子超載、氧自由基堆積、炎性因子的刺激等。其中炎癥應答 (inflammatory response) 是腦損傷病理生理過程中的一個重要組成環(huán)節(jié)，半胱氨酰白三烯 (cysteinyl LTs) 包括LTC4, LTD4 和 LTE4 是一類重要的炎癥反應介質 , 是花生四烯酸 5-脂氧合酶 (5-lipoxygenase,5-LOX) 的代謝產物。 CysLTs 通過激活半胱氨酰白三烯受體 ( 包括 CysLT1 和 CysLT2 受體 ), 參與多種炎癥病理過程 , 介導平滑肌痙攣 (smooth muscle constriction) 、微血管滲漏 (vascular leak) 等。近年研究證明 , CysLTs 除在哮喘、過敏性鼻炎等炎癥性疾病發(fā)病過程中起重要作用外 , 也參與腦卒中、腦外傷、腦腫瘤、癲癇等中樞神經系統(tǒng)疾病的病理生理過程。腦缺血后CysLTs 釋放增加 , 5-LOX 抑制劑能減少 CysLTs 的產生，從而保護腦缺血性損傷。
相關產品如下：
| 產品名稱 | 貨號 | 規(guī)格 | 供應商 |
| A-803467 | 10012588 | 5/10/50/100mg | Cayman |
| N-Ac-Tyr-Val-Ala-Asp-CMK | 10014 | 1/5/10/25mg | Cayman |
| AFMK | 10005254 | 1/5/10/50mg | Cayman |
| Agomelatine | 13203 | 5/10/50/100mg | Cayman |
| AL 34662 | 10011546 | 1/5/10/50mg | Cayman |
| AM251 | 71670 | 5/10/50/100mg | Cayman |
| AM404 | 90060 | 5/10/50/100mg | Cayman |
| AM630 | 10006974 | 5/10/50/100mg | Cayman |
| AM1172 | 10005223 | 1/5/10g/50mg | Cayman |
| AM1241 | 10010118 | 1/5/10/25mg | Cayman |
| (R)-AM1241 | 10491 | 1/5/10/25mg | Cayman |
| (S)-AM1241 | 10490 | 1/5/10/25mg | Cayman |
| AM3102 | 13452 | 5/10/25/50mg | Cayman |
| N-Arachidonoyl-L-Alanine | 90065 | 5/10/25/50mg | Cayman |
| Arachidonoyl Amide | 10007295 | 5/10/25/50mg | Cayman |
| AMC Arachidonoyl Amide | 10005098 | 5/10/25/50mg | Cayman |
| 7-Aminoclonazepam-d4* | 10010670 | 1/5/10mg | Cayman |
| β-Amyloid(1-8) Peptide | 10241 | 1ea | Cayman |
| β-Amyloid(1-8, A2V) Peptide | 10229 | 1ea | Cayman |
| Apelin-13 | 13523 | 1/5/10/25mg | Cayman |
| N-(3-hydroxyphenyl)-Arachidonoyl?Amide | 10007704 | 5/10/50/100mg | Cayman |
| 產品名稱 | 貨號 | 規(guī)格 | 供應商 |
| N-Arachidonoyl-γ-Aminobutyric Acid | 90067 | 5/10/25/50mg | Cayman |
| N-Arachidonoyl-3-hydroxy-γ-Aminobutyric Acid | 10158 | 1/5/10/50 mg | Cayman |
| Arachidonoyl 2’-Chloroethylamide | 91054 | 5/10/50/100mg | Cayman |
| Arachidonoyl Cyclopropylamide | 91053 | 5/10/50/100mg | Cayman |
| Arachidonoyl-N,N-dimethyl amide | 10007293 | 5/10/50/100mg | Cayman |
| N-Arachidonoyl Dopamine | 90057 | 5/10/50/100mg | Cayman |
| Arachidonoyl Ethanolamide | 90050 | 5/10/50/100mg | Cayman |
| oxy-Arachidonoyl Ethanolamide | 10008642 | 5/10/25/50mg | Cayman |
| Arachidonoyl Ethanolamide Phosphate | 10180 | 250ug/500ug,? 1mg/5mg | Cayman |
| O-Arachidonoyl Ethanolamine | 91050 | 1/5/10/25mg | Cayman |
| Arachidonoyl 2’-Fluoroethy-lamide | 90054 | 5/10/50/100mg | Cayman |
(±)-2-Methyl Arachidonoyl-2’-Fluoroethylamide | 90055 | 1/5/10/25mg | Cayman |
| Methyl Arachidonyl Fluorop-hosphonate | 70660 | 1/5/10/25mg | Cayman |
| Arachidonoyl-1-thio-Glycerol | 10007904 | 1/5/10/25mg | Cayman |
| 1-Arachidonoyl Glycerol | 62150 | 1/5/10/25mg | Cayman |
| 1-Arachidonoyl Glycerol-d5 | 362152 | 100ug/500ug /1mg/5mg | Cayman |
| 2-Arachidonoyl Glycerol | 62160 | 1/5/10/25mg | Cayman |
| 2-Arachidonoyl Glycerol-d5 | 362162 | 50ug/100ug /500ug/1mg | Cayman |
| 2-Arachidonoyl Glycerol-d8 | 362160 | 25/50/100/500ug | Cayman |
| O-Arachidonoyl Glycidol | 10010547 | 5/10/50/100mg | Cayman |
| Arachidonoyl Glycine | 90051 | 5/10/50/100mg | Cayman |
| Arachidonoyl-N-methyl amide | 10007294 | 5/10/50/100mg | Cayman |
| Arachidonoyl m-Nitroaniline | 90059 | 5/10/25/50mg | Cayman |
| Arachidonoyl Serinol | 62170 | 5/10/50/100mg | Cayman |
更多產品詳情，請聯系Cayman一級代理商-欣博盛生物
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