組胺是由氨基酸組氨酸合成的內源性短效生物胺，廣泛分布于全身。組胺是速發(fā)型過敏反應的一種重要介質。正常情況下，人體內僅存在少量的組胺。當一種物質進入人體時（比如食物、化學品、昆蟲叮咬、植物油脂），可能會引發(fā)過敏反應。作為對該分子的反應，身體就會釋放更大量的組胺并開始免疫反應。身體通過產生腎上腺素（腎上腺素）來平衡組胺的釋放，這可以幫助調節(jié)組胺的影響。由于組胺在免疫應答中的強有力作用，組胺在體內存在的時間很短暫，只能在釋放后幾分鐘內測定。組胺也是一類小分子神經遞質，這類物質包括5-羥色胺，腎上腺素和多巴胺等。此外，組胺在胃酸分泌中起作用，有助于誘導胃酸的產生。
ENZO Histamine ELISA kit是一種比色競爭法免疫測定試劑盒，可在2.5小時內得到檢測結果。
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?● 高靈敏度，可檢測低至0.03 ng / mL Histamine
?● 獨特的檢測方法，不需要額外的酰化步驟
?● 檢測范圍寬，適用于各種類型樣品
?●?高通量，可檢測多達40個樣品（帶復孔），2.5可獲得結果
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產品信息
產品貨號 | ENZ-KIT140A-0001 |
產品名稱 | Histamine ELISA kit（組胺ELISA試劑盒） |
規(guī)格 | 96 wells |
靈敏度 | 0.068 pg/ml |
檢測范圍 | 0.098-25 pg/ml |
檢測時間 | 2.5 hours |
樣本種屬 | Human, Mouse, Rat |
樣本類型 | tissue culture media, serum, plasma and urine in human, mouse, and rat (serum only) samples |
保存溫度 | Store all components at +4°C, except conjugate, antibody, and tracer, which are stored at -20°C |
試劑盒組分 | Microtiter Plate, Assay Buffer 13, Standard, Wash Buffer Concentrate, Antibody, Tracer, Conjugate, Substrate, and Stop Solution |
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部分產品文獻引用
1. The allergy mediator histamine confers resistanceto immunotherapy in cancer patients via activationof the macrophage histamine receptor H1: H. Li, et al.; Cancer Cell 40, 36 (2022)
2. Angelica gigas extract ameliorates allergic rhinitis in an ovalbumin-induced mouse model by inhibiting Th2 cell activation: K.Y. Ji, et al.; Phytomedicine 93, 153789 (2021)
3. Anti-allergic effects of Asarum heterotropoides on an ovalbumin-induced allergic rhinitis murine model: S. Choi, et al.; Biomed. Pharmacother. 141, 111944 (2021)
4. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis: R.D. Shelby, et al.; J. Pediatr. Surg. 22, 3468 (2021)
5. Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells: T. Kadowaki, et al.; FEBS Open Bio. 11, 1165 (2021), Application(s): Cell culture supernatant, BMMCs and RBL‐2H3?
6. Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells: S. Pal, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 318, R590 (2020), Application(s): Histamine concentration in lysates from rat mesenteric perilymphatic tissue
7. A connective tissue mast-cell-specific receptor detects bacterial quorum-sensing molecules and mediates antibacterial immunity: P. Pundir, et al.; Cell. Host. Microb. 26, 114 (2019), Application(s): Analysis of culture supernatants?
8. A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology: H. Chen, et al.; Cell 177, 1217 (2019), Application(s): Quantification of histamine production by 144 isolates of human gut bacteria
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