Y27632是一種具有細胞滲透性的ROCK抑制劑，能選擇性的抑制ROCK1(p160ROCK)和ROCK2。

CAS：?129830-38-2??

純度：>98%

保存：-20?°C避光保存。?

?

文獻引用

?-----------------------------------------------------------------------------------------------------------------------------?????

1.?The?effect?of?ROCK?on?TNF-α-induced?CXCL8?secretion?by?intestinal?epithelial?cell?lines?is?mediated?through?MKK4?and?JNK?signaling:?

????? A.C.?Perey,?et?al.;?Cell?Immunol.?293,?80?(2015),?Application(s):?Cell?Culture,?Abstract;

2.?Dissecting?the?roles?of?ROCK?isoforms?in?stress-induced?cell?detachment.?:?J.?Shi,?et?al.?;?Cell?Cycle?12,?1492,1500?(2013),Abstract;

3.?Distinct?roles?for?ROCK1?and?ROCK2?in?the?regulation?of?cell?detachment:?J.?Shi,?et?al.;?Cell?Death?Dis.?4,?e483?(2013),Abstract;?Full?Text;

4.?Conditionally?reprogrammed?cells?represent?a?stem-like?state?of?adult?epithelial?cells.?:?FA.?Suprynowicz,?et?al.?;?PNAS?109,?20035,20040?(2012),?

?????Abstract;

5.?ROCK?Inhibitor?and?Feeder?Cells?Induce?the?Conditional?Reprogramming?of?Epithelial?Cells?:?X.?Liu,?et?al.;?Am.?J.?Pathol.?180,?599,607?(2012),

?????Abstract;

6.?Use?of?reprogrammed?cells?to?identify?therapy?for?respiratory?papillomatosis.?:?H.?Yuan,?et?al.?;?N?Engl?J?Med?367,?1220,1227?(2012),?Abstract;

7.?Small?molecule?inhibition?of?cytoskeletal?dynamics?in?melanoma?tumors?results?in?altered?transcriptional?expression?patterns?of?key?genes?

?????involved?in?tumor?initiation?and?progression:?C.?Spencer,?et?al.;?Cancer?Genom.?Proteom.?8,?77?(2011),?Abstract;

8.?Effects?of?rho-kinase?inhibition?on?pulmonary?hypertension,?lung?growth,?and?structure?in?neonatal?rats?chronically?exposed?to?hypoxia.?:?AJ.?Ziino,?

???? et?al.;?Pediatr?Res.?67,?177,82?(2010),?Abstract;

9.?The?proline-rich?region?of?HIV-1?Nef?affects?CXCR4-mediated?chemotaxis?in?Jurkat?T?cells:?C.M.?Lee,?et?al.;?Viral?Immunol.?21,?347?(2008),?Abstract;

10.?A?Rho-kinase?inhibitor,?Y-27632,?reduces?cholinergic?contraction?but?not?neurotransmitter?release:?L.?Fernandes,?et?al.;?Eur.?J.?Pharmacol.?550,?

???? 155?(2006),?Abstract;

11.?Molecular?characterization?of?the?effects?of?Y-27632:?H.?Darenfed,?et?al.;?Cell?Motil.?Cytoskeleton?(2006),?Abstract;

12.?Rho-kinase?inhibitor,?Y-27632,?has?an?antinociceptive?effect?in?mice:?K.?Buyukafsar,?et?al.;?Eur.?J.?Pharmacol.?541,?49?(2006),Abstract;

13.?Structural?basis?for?induced-fit?binding?of?Rho-kinase?to?the?inhibitor?Y-27632:?H.?Yamaguchi,?et?al.;?J.?Biochem?(Tokyo)?140,?305?(2006),?Abstract;

14.?Preventive?effect?of?Y-27632,?a?selective?Rho-kinase?inhibitor,?on?ischemia/reperfusion-induced?acute?renal?failure?in?rats:?K.?Teraishi,?et?al.;?

?????? Eur.?J.?Pharmacol.?505,?205?(2004),?Abstract;

15.?Comparison?of?effects?of?Y-27632?and?Isoproterenol?on?release?of?cytokines?from?human?peripheral?T?cells:?M.?Aihara,?et?al.;?Int.?Immunopharmacol.?

??? ??3,?1619?(2003),?Abstract;

16.?Inhibition?of?high?K+-induced?contraction?by?the?ROCKs?inhibitor?Y-27632?in?vascular?smooth?muscle:?possible?involvement?of?ROCKs?in?a?signal?

???????transduction?pathway:?K.?Sakamoto,?et?al.;?J.?Pharmacol.?Sci.?92,?56?(2003),?Abstract;

17.?Protein?kinase?A?in?complex?with?Rho-kinase?inhibitors?Y-27632,?Fasudil,?and?H-1152P:?structural?basis?of?selectivity:?C.?Breitenlechner,?et?al.;?

?????? Structure?11,?1595?(2003),?Abstract;

18.?Y-27632,?a?Rho-kinase?inhibitor,?inhibits?proliferation?and?adrenergic?contraction?of?prostatic?smooth?muscle?cells:?R.W.?Rees,?et?al.;?J.?Urol.?

???????170,?2517?(2003),?Abstract;

19.?Antagonism?of?Rho-kinase?stimulates?rat?penile?erection?via?a?nitric?oxide-independent?pathway:?K.?Chitaley,?et?al.;?Nat.?Med.?7,?119?(2001),

????? ?Abstract;

20.?Inhibition?of?intrahepatic?metastasis?of?human?hepatocellular?carcinoma?by?Rho-associated?protein?kinase?inhibitor?Y-27632:?M.?Takamura,?

????? et?al.;?Hepatology?33,?577?(2001),?Abstract;

21.?A?p160ROCK-specific?inhibitor,?Y-27632,?attenuates?rat?hepatic?stellate?cell?growth:?H.?Iwamoto,?et?al.;?J.?Hepatol.?32,?762?(2000),?Abstract;

22.?Pharmacological?properties?of?Y-27632,?a?specific?inhibitor?of?rho-associated?kinases:?T.?Ishizaki,?et?al.;?Mol.?Pharmacol.?57,?976?(2000),?Abstract;

23.?Specificity?and?mechanism?of?action?of?some?commonly?used?protein?kinase?inhibitors:?S.P.?Davies,?et?al.;?Biochem.?J.?351,?95?(2000),?Abstract;?Full?Text

24.?The?effect?of?a?Rho?kinase?inhibitor?Y-27632?on?superoxide?production,?aggregation?and?adhesion?in?human?polymorphonuclear?leukocytes:?A.?Ka

???????waguchi,?et?al.;?Eur.?J.?Pharmacol.?403,?203?(2000),?Abstract;

25.?Use?and?properties?of?ROCK-specific?inhibitor?Y-27632:?S.?Narumiya,?et?al.;?Meth.?Enzymol.?325,?273?(2000),?Abstract;

26.?Y-27632,?an?inhibitor?of?rho-associated?protein?kinase,?suppresses?tumor?cell?invasion?via?regulation?of?focal?adhesion?and?focal?adhesion?kinase:?F.?Ima

?????? mura,?et?al.;?Jpn.?J.?Cancer?Res.?91,?811?(2000),?Abstract;

27.?Signaling?from?Rho?to?the?actin?cytoskeleton?through?protein?kinases?ROCK?and?LIM-kinase:?M.?Maekawa,?et?al.;?Science?285,?895?(1999),?Abstract;

28.?Molecular?dissection?of?the?Rho-associated?protein?kinase?(p160ROCK)-regulated?neurite?remodeling?in?neuroblastoma?N1E-115?cells:?M.?Hirose,?et?al.;?

????? J.?Cell?Biol.?141,?1625?(1998),?Abstract;

29.?Calcium?sensitization?of?smooth?muscle?mediated?by?a?Rho-associated?protein?kinase?in?hypertension:?M.?Uehata,?et?al.;?Nature389,?990?(1997),?Abstract;