神經(jīng)節(jié)苷脂是酸性鞘糖脂,其在細(xì)胞質(zhì)膜的外部小葉中形成脂筏,特別是在中樞神經(jīng)系統(tǒng)的神經(jīng)元細(xì)胞中。它們參與細(xì)胞增殖、分化、粘附、信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞間相互作用、腫瘤發(fā)生和轉(zhuǎn)移,神經(jīng)節(jié)苷脂的積累與幾種疾病有關(guān)。神經(jīng)節(jié)苷脂GT1b可結(jié)合肉毒桿菌和破傷風(fēng)神經(jīng)毒素,并防止谷氨酸對(duì)神經(jīng)元細(xì)胞的神經(jīng)毒性。
產(chǎn)品詳情
別名:GT1b . 3Na; Trisialoganglioside GT1b . 3Na
來(lái)源:Isolated from bovine brain.
分子式:C95H162N5O47 . 3Na
分子量:2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid)
CAS號(hào):59247-13-1
純度:≥98% (TLC)
該產(chǎn)品自上市以來(lái)有多篇文獻(xiàn)引用,品質(zhì)有保證,以下是最新發(fā)表的文獻(xiàn)引用:
1.The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid: A. Yoshimura, et al.; BBRC in press, (2020)
2.Analysis of biochemical features of ST8 α?N?acetyl?neuraminide α2,8?sialyltransferase (St8sia) 5 isoforms: E. Araki, et al.; Glycoconj. J. ahead of print (2022)
產(chǎn)品訂購(gòu)
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