神經(jīng)節(jié)苷脂是酸性鞘糖脂，其在細胞質(zhì)膜的外部小葉中形成脂筏，特別是在中樞神經(jīng)系統(tǒng)的神經(jīng)元細胞中。它們參與細胞增殖、分化、粘附、信號轉(zhuǎn)導(dǎo)、細胞間相互作用、腫瘤發(fā)生和轉(zhuǎn)移，神經(jīng)節(jié)苷脂的積累與幾種疾病有關(guān)。神經(jīng)節(jié)苷脂GD1b可作為細菌毒素受體（破傷風(fēng)、肉毒桿菌），在膠質(zhì)瘤和星形細胞瘤中數(shù)量高，它可調(diào)節(jié)蛋白激酶活性。在體內(nèi)和體外，它與內(nèi)酯結(jié)構(gòu)處于平衡狀態(tài)。

產(chǎn)品詳情

別名：GD1b . 2Na; Disialoganglioside GD1b . 2Na

來源：Isolated from bovine brain.

分子式：C84H146N4O39 . 2Na

分子量：1836.1 . 46.0 (calculated on sphingosine

C18:1 and stearic acid)

CAS號：19553-76-5

純度：≥98% (TLC)

訂購信息

部分產(chǎn)品文獻

1.Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)

2.Natural occurrence of ganglioside lactones. Isolation and characterization of GD1b inner ester from adult human brain: L. Riboni, et al.; J. Biol. Chem. 261, 8514 (1986)

3.Exogenous gangliosides GD1b and GD1b-lactone, stably associated to rat brain P2 subcellular fraction, modulate differently the process of protein phosphorylation: R. Bassi, et al.; J. Neurochem. 57, 1207 (1991)

4.Immunohistochemical staining for ganglioside GD1b as a diagnostic and prognostic marker for primary human brain tumors: T.C. Comas, et al.; Neuro Oncol. 1, 261 (1999)

5.Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)

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