Adipogen開(kāi)發(fā)了可以用于體內(nèi)實(shí)驗(yàn)作為阻斷劑的小鼠的抗BAFF單克隆抗體，為腫瘤學(xué)、免疫學(xué)、免疫治療、自身免疫性疾病，小鼠模型體內(nèi)實(shí)驗(yàn)等研究領(lǐng)域的實(shí)驗(yàn)者們對(duì)BAFF通路的研究提供了強(qiáng)有力的工具。?。
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B細(xì)胞激活因子（BAFF）又稱腫瘤壞死因子配體超家族成員13B，是一種由TNFSF13B基因編碼的蛋白質(zhì)，由巨噬細(xì)胞、單核細(xì)胞、樹(shù)突狀細(xì)胞（DC）、受刺激的中性粒細(xì)胞和基質(zhì)細(xì)胞表達(dá)的TNF超家族成員。BAFF是外周血B細(xì)胞存活的主要調(diào)節(jié)因子，調(diào)節(jié)外周B細(xì)胞穩(wěn)態(tài)，促進(jìn)B細(xì)胞存活和分化，與IL-6一起促進(jìn)Ig類轉(zhuǎn)換和漿細(xì)胞分化。在BAFF的外周淋巴系統(tǒng)中?/? 小鼠成熟B淋巴細(xì)胞明顯減少。在轉(zhuǎn)基因（TG）小鼠中過(guò)度產(chǎn)生BAFF會(huì)導(dǎo)致脾臟增大，成熟B細(xì)胞數(shù)量增加，并產(chǎn)生類似RA和系統(tǒng)性紅斑狼瘡（SLE）的自身免疫性疾病。BAFF可以通過(guò)增強(qiáng)T細(xì)胞與T細(xì)胞受體的共刺激信號(hào)的產(chǎn)生來(lái)調(diào)節(jié)T細(xì)胞的功能。
在患有各種自身免疫性疾病的患者血清中檢測(cè)到可溶性BAFF水平升高，如干燥綜合征、類風(fēng)濕性關(guān)節(jié)炎、多發(fā)性硬化和系統(tǒng)性紅斑狼瘡（SLE）。此外，BAFF存在于炎癥部位，其中存在淋巴新生。多發(fā)性骨髓瘤和B細(xì)胞慢性淋巴細(xì)胞白血病（B-CCL）患者的BAFF水平升高。
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產(chǎn)品信息：?
貨號(hào)：AG-20B-0063PF
名稱：anti-BAFF (mouse), mAb (blocking) (Sandy-2) (preservative free)
規(guī)格：100 μg、500 μg
反應(yīng)種屬：Mouse
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克隆號(hào)：Sandy-2
同型：Mouse IgG1κ
來(lái)源：Purified from concentrated hybridoma tissue culture supernatant
抗原/免疫原：Recombinant mouse BAFF
特異性：Recognizes mouse BAFF
應(yīng)用：
Functional Application:?Inhibition of mouse BAFF binding to BAFF-R and TACI (BCMA not tested); blocks BAFF activity in mice.?Injection of the anti-BAFF (mouse), mAb (Sandy-2) in mice creates a BAFF KO phenotype within 2 weeks, that can be maintained as long as necessary (> 6 months) by further injections of Sandy-2 every 2 weeks.
Immunoprecipitation:?(1:200)
同型對(duì)照：Mouse IgG1 Isotype Control (preservative free) （AG-35B-0003PF）
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純度：≥95% (SDS-PAGE)
內(nèi)毒素含量：<0.01EU/μg purified protein (LAL test).
濃度：1mg/ml
提供形式：液體
保存條件：4度保存。
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結(jié)果例圖：
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anti-BAFF (mouse), mAb (Sandy-2) (preservative free) (Prod. No. AG-20B-0063PF) blocks the action of endogenous BAFF?in vivo.
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參考文獻(xiàn)：
1.?Depletion of BAFF cytokine exacerbates infection in Pseudomonas aeruginosa infected mice: D. Garic, et al.; J. Cyst. Fibr. 18, 349 (2019)
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2.?No interactions between heparin and atacicept, an antagonist of B cell survival cytokines: C. Kowalczyk
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3.?Incorporating B cell activating factor (BAFF) into the membrane of rabies virus (RABV) particles improves the speed and magnitude of vaccine-induced antibody responses: J.R. Plummer & J.P. McGettigan; PLoS 13, e0007800 (2019)
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4.?B cell-activating factor modulates the factor VIII immune response in hemophilia A: B.S. Doshi, et al.; J. Clin. Invst. 131, 142906 (2021)
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5.?B cell activating factor antagonism attenuates the growth of experimental abdominal aortic aneurysm: M.D. Spinosa, et al.; Am. J. Pathol. 191, 2231 (2021)
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6.?B cell activating factor regulates periodontitis development by suppressing inflammatory responses in macrophages: L. Wang, et al.; BMC Oral Health 21, 426 (2021）
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訂購(gòu)詳情：?
貨號(hào) | 名稱 | 規(guī)格 |
AG-20B-0063PF-C100 | anti-BAFF (mouse), mAb (blocking) (Sandy-2) (preservative free) | 100 μg、500 μg |
AG-20B-0063-C100 | anti-BAFF (mouse), mAb (blocking) (Sandy-2) | 100 μg |
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