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CleanCap?AG (3'OMe)用于mRNA的共轉(zhuǎn)錄，m7(3'OMeG)(5')ppp(5')(2'OMeA)pG
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產(chǎn)品描述：
CleanCap?AG (3' OMe)是TriLink公司的專有的共轉(zhuǎn)錄加帽試劑，用于5 '帽端mRNA轉(zhuǎn)錄，形成Cap 1結(jié)構(gòu)。CleanCap的加帽效率高達(dá)98%。Trilink N-7413TrilinkCleanCap?Reagent AG共轉(zhuǎn)錄產(chǎn)品的cap1mRNA要比 mCAP和ARCA加帽產(chǎn)生的cap0 mRNA活性更好。
產(chǎn)品信息：
| 產(chǎn)品貨號(hào) | N-7413 |
| 純度 | ≥95% by AX-HPLC |
| 消光系數(shù) | 30,539 Lmol-1cm-1?at 255 nm |
| 分子式 | C33H45N15O24P4?(游離酸) |
| 分子質(zhì)量 | 1159.6 |
| 鹽形式 | Na+ |
| 濃度 | 100 mM |
| 溶液組分 | 水 |
| 推薦的儲(chǔ)存溫度 | -20°C?或者以下 |
| 其他名稱 | CleanCap??Reagent AG(3'?OMe)?for co-transcriptional capping of mRNA,?m7(3'OMeG)(5’)ppp(5')(2'OMeA)pG |
| 應(yīng)用 | CRISPR, In vitro Transcription, Recombinases, TALENS, Transposases, Vaccine Development, Zinc Finger Nucleases |
| 主鏈 | 5'-5'-三磷酸 |
| 堿基類似物 | 腺苷酸，鳥苷酸 |
| 核苷酸種類 | 帽類似物
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產(chǎn)品規(guī)格如下：
| 供應(yīng)商 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | 規(guī)格 |
| TriLink | N-7413-1 | CleanCap Reagent??AG（3'OMe）,??1 umole | 1 umol |
| TriLink | N-7413-5 | CleanCap Reagent??AG（3'OMe）,??5?umole | 5?umol |
| TriLink | N-7413-10 | CleanCap Reagent??AG（3'OMe）,??10?umole | 10 umol |
| TriLink | N-7413-100 | CleanCap Reagent??AG（3'OMe）,??100?umole | 100?umol |
文獻(xiàn)引用；
● Rothgangl, T;Dennis, MK;Lin, PJC;Oka, R;Witzigmann, D;Villiger, L;Qi, W;Hruzova, M;Kissling, L;Lenggenhager, D;Borrelli, C;Egli, S;Frey, N;Bakker, N;Walker, JA;Kadina, AP;Victorov, DV;Pacesa, M;Kreutzer, S;Kontarakis, Z;Moor, A;Jinek, M;Weissman, D;Stoffel, M;van Boxtel, R;Holden, K;Pardi, N;Th . In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels?
●?Weissman, D;Alameh, MG;de Silva, T;Collini, P;Hornsby, H;Brown, R;LaBranche, CC;Edwards, RJ;Sutherland, L;Santra, S;Mansouri, K;Gobeil, S;McDanal, C;Pardi, N;Hengartner, N;Lin, PJC;Tam, Y;Shaw, PA;Lewis, MG;Boesler, C;?ahin, U;Acharya, P;Haynes, BF;Korber, B;Montefiori, DC; . D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization?
●?Pandey, RR;Delfino, E;Homolka, D;Roithova, A;Chen, KM;Li, L;Franco, G;V . The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues?
●?Mu, Z;Wiehe, K;Saunders, KO;Henderson, R;Cain, DW;Parks, R;Martik, D;Mansouri, K;Edwards, RJ;Newman, A;Lu, X;Xia, SM;Bonsignori, M;Montefiori, D;Han, Q;Venkatayogi, S;Evangelous, T;Wang, Y;Rountree, W;Tam, Y;Barbosa, C;Munir Alam, S;Williams, WB;Pardi, N;Weissman, D;Haynes, BF; . Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles?
●?Martinez, DR;Schaefer, A;Leist, SR;De la Cruz, G;West, A;Atochina-Vasserman, EN;Parks, R;Barr, M;Li, D;Yount, B;Saunders, KO;Weissman, D;Haynes, BF;Montgomery, SA;Baric, RS; . Chimeric spike mRNA vaccines protect against sarbecovirus challenge in mice
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