法國InvivoGen最新推出人TLR2/1 & TLR2/6, 小鼠TLR2/1 信號抑制劑TL2-C29，為TLR2信號研究的科研人員提供最新工具。
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TL2-C29 是一種Toll樣受體2 (TLR2)的小分子抑制劑?[1]，TLR2在檢測來自細(xì)菌、真菌、寄生蟲和病毒的多種病原相關(guān)分子模式（PAMPs）中起著非常重要的作用 [2]。TLR1和TLR6的共受體(co-receptors)對TLR2 信號和配體的特異性有關(guān)鍵影響。細(xì)胞表面的TLR2/TLR1和TLR2/TLR6異二聚體可分別結(jié)合三?；投；鞍?/span> [3,4]。TLR2信號是由配體誘導(dǎo)的TLR2異二聚體和銜接蛋白（adapter proteins）的基本細(xì)胞質(zhì)TIR（Toll/IL-1受體）結(jié)構(gòu)域的二聚化啟動。隨后的信號級聯(lián)導(dǎo)致促炎癥反應(yīng)。
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TL2-C29抑制TLR2信號作用機(jī)理
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產(chǎn)品信息
名稱：TL2-C29
規(guī)格：5mg
貨號：inh-c29
別名:?C29; TLR2-IN-C29; 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid
CAS號:?363600-92-4
分子式:?C16H15NO4
分子量:?285.3 g/mol
溶解度:?50 mM (14.3 mg/ml) in DMSO
工作濃度:?25 - 200 μM for cell culture assays.
質(zhì)控:
? ? ?·?Purity ≥ 95% (NMR)
? ? ?·?Inhibition of human TLR2/1 and TLR2/6 signaling has been confirmed using cellular assays
? ? ?·?The absence of bacterial contamination (e.g. lipoproteins and endotoxins) has been confirmed using?HEK-Blue? TLR2?and?HEK Blue? TLR4?cells.
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主要特點:
-人TLR2/1和TLR2/6信號的高效抑制劑
-小鼠TLR2/1信號的高效抑制劑
-無明顯細(xì)胞毒性
-在細(xì)胞試驗上驗證可抑制NF-κB/AP-1信號
-每個批次純度均大于≥ 95%，并經(jīng)過功能性測試
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InvivoGen實驗室數(shù)據(jù)支持
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相關(guān)產(chǎn)品推薦
產(chǎn)品名稱 | 描述 |
Pam3CSK4? | TLR2/TLR1 Agonist - Synthetic triacylated lipopeptide |
Pam2CSK4? | TLR2/TLR6 Agonist - Synthetic diacylated lipopeptide |
FSL-1? | TLR2/TLR6 Agonist - Synthetic diacylated lipoprotein |
HKLM? | TLR2 Agonist - Heat Killed Listeria monocytogenes |
HKPA? | TLR2 Agonist - Heat Killed - Pseudomonas aeruginosa |
HEK-Blue? hTLR2? | Human TLR2 / NF-κB / SEAP reporter HEK293 cells |
QUANTI-Blue?? | Alkaline phosphatase detection medium |
HEK-Blue? hTLR2-TLR1? | Human TLR2+TLR1 / NF-κB / SEAP reporter HEK293 cells |
HEK-Blue? hTLR2-TLR6? | Human TLR2+TLR6 / NF-κB / SEAP reporter HEK293 cells |
HEK-Blue? hTLR2 KO-TLR1/6? | Human TLR2 (KO-TLR1/6) / NF-κB / SEAP reporter HEK293 cells |
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參考文獻(xiàn)
1. Mistry, P.?et al., 2015.?Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. PNAS. 112(17):5455-5460.
2. Oliveira-Nascimento L.?et al.,?2012.?The role of TLR2 in infection and Immunity. Front Immunol. 3(79): doi:10.3389/fimmu.2012.00079.
3. Takeuchi O.?et al.,?2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol. 13: 933-940.
4. Takeuchi O.?et al.,?2002.?Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 169: 10-14
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