2021 年 11 月 26 日,WHO 將 SARS-CoV-2 變體 B.1.1.529 指定為第五種關(guān)注變體 (VOC),并將其命名為“Omicron”,在其基因組中的 50 多個(gè)突變中,至少有 32 個(gè)位于棘突蛋白,其中 RBD 有 15 個(gè)點(diǎn)突變(圖 1);與其他 VOC 一樣,在 Omicron 的核蛋白中也發(fā)現(xiàn)了突變(圖 2);Omicron 分布廣泛,勝過(guò) Delta,盡管它似乎會(huì)導(dǎo)致更輕微的疾病,但它仍然導(dǎo)致住院人數(shù)增加。?
圖 1. Spike mutation sites found in Omicron are A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F.
圖 2. Nucleocapsid protein mutation sites found in Omicron are P13L, Δ31-33, R203M, G204R, and in Delta are D63G, R203M, G215C, D377Y.
GeneTex 提供一系列用于Omicron 研究的重組抗體和蛋白質(zhì)試劑,值得注意的是,其免疫原不包含任何 Omicron 突變位點(diǎn)的棘蛋白和核蛋白抗體如圖 2 所示。請(qǐng)參閱下面的精選產(chǎn)品列表以及表格所選抗體對(duì)VOC的反應(yīng)性。
精選產(chǎn)品
SARS-CoV-2 (COVID-19) Spike RBD Protein, B.1.1.529 / Omicron variant, His tag?(GTX136716-pro)
SARS-CoV-2 (COVID-19) nucleocapsid protein, B.1.1.529 / Omicron variant, His tag?(GTX136779-pro)
SARS-CoV-2 (COVID-19) Spike (ECD) Protein, B.1.1.529 / Omicron variant, His tag?(GTX136780-pro)
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL257]?(GTX635692)
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SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1014]?(GTX635807)
抗體對(duì) | 產(chǎn)品名 | EC50 | 目錄號(hào) |
Pair I | Nucleocapsid antibody [HL5511] | 14 pM | GTX635689 |
Pair I | Nucleocapsid antibody [HL448] | 11 pM | GTX635686 |
Pair II | Nucleocapsid antibody [HL5410] | 9 pM | GTX635685 |
Pair II | Nucleocapsid antibody [HL455] | 6 pM | GTX635688 |
產(chǎn)品名 | 目錄號(hào) | WIV04/2019 | B.1.617.2 | B.1.1.529 |
Spike RBD antibody [HL1014] | GTX635807 | ● | ● | ● |
Spike RBD antibody [HL1002] | GTX635791 | ● | ● | X |
Spike RBD antibody [HL1003] | GTX635792 | ● | ● | ● |
Spike RBD antibody [HL1004] | GTX635793 | ● | ● | ● |
Spike S1 antibody [HL13402] | GTX635713 | ● | ● | X |
Spike S1 antibody [GT263] | GTX635708 | X | 未檢測(cè) | X |
Spike antibody [1A9] | GTX632604 | ● | ● | ○ |
Spike S2 antibody [HL237] | GTX635693 | ○ | ● | ● |
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