炎癥性腸病(IBDs)是一種全球性疾病,發(fā)病率在發(fā)展中國家呈上升趨勢,該病常反復發(fā)作,嚴重影響患者的正常生活。生物鐘系統(tǒng)是生物體內生的“振蕩器”,控制著多種生理和行為進程,生物鐘與炎癥性疾病關系密切,生物鐘還可能是炎癥性疾病癥狀產生晝夜差異的重要因素。盡管晝夜節(jié)律如何影響炎癥越來越明了,但炎癥調節(jié)晝夜節(jié)律的分子機制仍然難以捉摸。LncRNA(長非編碼RNA)是一類非編碼RNA,可通過核苷酸堿基配對或RNA折疊產生的結構域的形成,與DNA,其他RNA和蛋白質發(fā)生相互作用,從而調節(jié)基因轉錄。一些lncRNA與免疫反應有關,在炎癥反應(如內毒素血癥和腎炎)的發(fā)生中發(fā)揮作用。另外,lncRNA對生物鐘有潛在的影響,還可能受生物鐘的控制。然而,lncRNA在結腸炎與晝夜節(jié)律的交互作用中的作用在很大程度上是未知的。
近期,暨南大學吳寶劍教授團隊在Science Advances上發(fā)表了題為” An NF-κB-driven lncRNA orchestrates colitis and circadian clock?”的研究論文,該研究發(fā)現(xiàn)NF-κB驅動的一種周期性表達的lncRNA——Lnc-UC,能通過表觀遺傳機制調控有抗炎作用的節(jié)律基因Rev-erbα的表達,從而將晝夜節(jié)律和結腸炎聯(lián)系起來。靶向Lnc-UC可能是干預炎癥與生物鐘之間的互相作用,并控制結腸炎的新策略。
本文中使用了欣博盛Mouse IL-1β and IL-18 ELISA試劑盒,檢測了小鼠骨髓來源的巨噬細胞培養(yǎng)基中IL-1β和IL-18的濃度。
以下是2020年10月欣博盛品牌產品SCI文獻引用:
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1.文章題目:An NF-κB-driven lncRNA orchestrates colitis and circadian clock.
期 ???刊:Science Advances(影響因子:13.116)
發(fā)表時間:14 October 2020
作 ???者:Wang S, Lin Y, Li F, et al.
作者單位:暨南大學?
使用產品:Mouse IL-1β and IL-18 ELISA Kits ???????
https://pubmed.ncbi.nlm.nih.gov/33055157/
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2.文章題目:ROS Responsive Nanoplatform with Two-Photon AIE Imaging for Atherosclerosis Diagnosis and “Two-Pronged”?Therapy.
期 ???刊:Small(影響因子:11.459)
發(fā)表時間:20 October 2020
作 ???者:Ma B, Xu H, Zhuang W, et al.
作者單位:四川大學
使用產品:Mouse TNF-α and IL-1β ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/33078569/
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3.文章題目:Nanoparticle-Enabled Dual Modulation of Phagocytic Signals to Improve Macrophage-Mediated Cancer Immunotherapy.
期 ???刊:Small(影響因子:11.459)
發(fā)表時間:26 October 2020
作 ???者:Zhang Y R, Luo J Q, Zhang J Y, et al.
作者單位:華南理工大學
使用產品:Mouse IgG2a ELISA Kits??
https://pubmed.ncbi.nlm.nih.gov/33107142/
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4.文章題目:Black phosphorus quantum dots doped multifunctional hydrogel particles for cancer immunotherapy.
期 ???刊:Chemical Engineering Journal(影響因子:10.652)
發(fā)表時間:15 October 2020
作 ???者:Shou X, Liu Y, Wu D, et al.
作者單位:溫州醫(yī)科大學附屬第二醫(yī)院
使用產品:Human granzyme B and perforin ELISA Kits ??
https://www.sciencedirect.com/science/article/abs/pii/S1385894720334732
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5.文章題目:Multifunctional Nanoparticles Boost Cancer Immunotherapy Based on Modulating the Immunosuppressive Tumor Microenvironment.
期 ???刊:ACS Applied Materials & Interfaces(影響因子:8.758)
發(fā)表時間:30 October 2020
作 ???者:Li J, Zhao M, Sun M, et al.
作者單位:沈陽藥科大學
使用產品:Mouse?IFN-γ, TNF-α, IL-1β,TGF- β1,IL-10 and IL-12 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33124808/
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6.文章題目:Stromal cells and B cells orchestrate ectopic lymphoid tissue formation in nasal polyps.
期 ???刊:Allergy(影響因子:8.706)
發(fā)表時間:06 October 2020
作 ???者:Wang Z Z, Song J, Wang H, et al.
作者單位:華中科技大學同濟醫(yī)院
使用產品:Human?IL-17A ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/33022771/
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7.文章題目:Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma.
期 ???刊:Nano Research(影響因子:8.183)
發(fā)表時間:13 October 2020
作 ???者:Zhang L, Jia Y, Huang Y, et al.
作者單位:浙江大學?
使用產品:Mouse IFN-γ ELISA Kit
https://www.researchgate.net/publication/344627102_Efficient_delivery_of_clay-based_nanovaccines_to_the_mouse_spleen_promotes_potent_anti-tumor_immunity_for_both_prevention_and_treatment_of_lymphoma
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8.文章題目:microRNA-146a-5p negatively modulates PM2. 5 caused inflammation in THP-1 cells via autophagy process.
期 ???刊:Environmental Pollution(影響因子:6.792)
發(fā)表時間:29 October 2020
作 ???者:Shang Y, Liu Q, Wang L, et al.
作者單位:上海大學
使用產品:Human IL-8 ELISA Kit
https://www.sciencedirect.com/science/article/abs/pii/S0269749120366501
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9.文章題目:Chlorogenic Acid Suppresses miR-155 and Ameliorates Ulcerative Colitis Through the NF-κB?/NLRP3 inflammasome Pathway.
期 ???刊:Molecular Nutrition & Food Research(影響因子:5.309)
發(fā)表時間:20 October 2020
作 ???者:Zeng J, Zhang D, Wan X, et al.
作者單位:三峽大學
使用產品:Mouse?IL-1β ELISA Kits??????
https://pubmed.ncbi.nlm.nih.gov/33078870/
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10.文章題目:Study on the regulatory effects and mechanisms of action of bifidobacterial exopolysaccharides on anaphylaxes in mice.
期 ???刊:International Journal of Biological Macromolecules(影響因子:5.162)
發(fā)表時間:1 October 2020
作 ???者:Luo M, Yu X M, Min G, et al.
作者單位:南昌大學
使用產品:Mouse IgE, IgG, IL-4, IL-5, IL-13 and?IFN-γ ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0141813020345876
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11.文章題目:Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells.
期 ???刊:Cell & Bioscience(影響因子:5.026)
發(fā)表時間:27 October 2020
作 ???者:Zhang Q, Zhang J, Tian Y, et al.
作者單位:北京市神經外科研究所
使用產品:Human IL-15 and VEGF ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/33133514/
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12.文章題目:A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer.
期 ???刊:Frontiers in Oncology(影響因子:4.848)
發(fā)表時間:16 October 2020
作 ???者:Wang G, Guo S, Zhang W, et al.
作者單位:北京協(xié)和醫(yī)科大學
使用產品:Annexin V-FITC/PI apoptosis assay kit
https://www.frontiersin.org/articles/10.3389/fonc.2020.575711/full
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13.文章題目:Interleukin-5 deletion promotes sepsis-induced M1 macrophage differentiation, deteriorates cardiac dysfunction, and exacerbates cardiac injury via the NF-κB?p65 pathway in mice.
期 ???刊:BioFactors(影響因子:4.734)
發(fā)表時間:11 October 2020
作 ???者:Liang W, Li J, Bai C, et al.
作者單位:新鄉(xiāng)醫(yī)學院第一附屬醫(yī)院
使用產品:Mouse?IL-5, IL-1β, IL-6, IL-17, TNF-α and IFN-γ ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/33043521/
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14.文章題目:Neuroprotective Effect of Fractalkine on Radiation-induced Brain Injury Through Promoting the M2 Polarization of Microglia.
期 ???刊:Molecular Neurobiology(影響因子:4.5)
發(fā)表時間:22 October 2020
作 ???者:Wang J, Pan H, Lin Z, et al.
作者單位:華中科技大學同濟醫(yī)學院附屬協(xié)和醫(yī)院腫瘤中心
使用產品:Mouse TNF-α and IL-10 ELISA Kits ??
樣本類型:大腦組織
https://pubmed.ncbi.nlm.nih.gov/33089423/
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15.文章題目:IL-38: A novel cytokine in systemic lupus erythematosus pathogenesis.
期 ???刊:Journal of Cellular and Molecular Medicine(影響因子:4.486)
發(fā)表時間:20 October 2020
作 ???者:Xu W D, Su L C, Liu X Y, et al.
作者單位:西南醫(yī)科大學
使用產品:Human IL-38 ELISA Kit ???
https://pubmed.ncbi.nlm.nih.gov/33079487/
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16.文章題目:Intra-articular platelet-rich plasma combined with hyaluronic acid injection for knee osteoarthritis is superior to PRP or HA alone in inhibiting inflammation and improving pain and function.
期 ???刊:Arthroscopy: The Journal of Arthroscopic & Related Surgery(影響因子:4.325)
發(fā)表時間:20 October 2020
作 ???者:Xu Z, He Z, Shu L, et al.
作者單位:貴州醫(yī)科大學附屬醫(yī)院
使用產品:Human TIMP-1, IL-1β and TNF-α ELISA Kits
樣本類型:關節(jié)滑膜液
https://www.sciencedirect.com/science/article/abs/pii/S0749806320308434
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17.文章題目:Discovery of a novel rice derived peptide with significant anti-gout potency.
期 ???刊:Food & Function(影響因子:4.171)
發(fā)表時間:21 October 2020
作 ???者:Liu N, Meng B, Zeng L, et al.
作者單位:昆明醫(yī)科大學
使用產品:Mouse?IL-1β ELISA Kit???
https://pubs.rsc.org/en/content/articlehtml/2020/fo/d0fo01774d
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18.文章題目:Streptococcus thermophiles DMST-H2 Promotes Recovery in Mice with Antibiotic-Associated Diarrhea.
期 ???刊:Microorganisms(影響因子:4.152)
發(fā)表時間:24 October 2020
作 ???者:Hu J, Huang Y, Kuang J, et al.
作者單位:華南理工大學
使用產品:Mouse?TNF-α, IL-10 and IFN-γ ELISA Kits????
https://pubmed.ncbi.nlm.nih.gov/33114373/
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19.文章題目:Salviplenoid A from Salvia plebeia attenuates acute lung inflammation via modulating NF-κB and Nrf2 signaling pathways.
期 ???刊:Phytotherapy Research(影響因子:4.087)
發(fā)表時間:23 October 2020
作 ???者:Huang J L, Fan R Z, Zou Y H, et al.
作者單位:中山大學
使用產品:Mouse TNF-α, IL-1β?and IFN-γ ELISA Kits
樣本類型:支氣管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/33098234/
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20.文章題目:Protocatechualdehyde attenuates obstructive nephropathy through inhibiting lncRNA9884 induced inflammation.
期 ???刊:Phytotherapy Research(影響因子:4.087)
發(fā)表時間:28 October 2020
作 ???者:Yang J, Li J, Tan R, et al.
作者單位:西南醫(yī)科大學附屬中醫(yī)醫(yī)院
使用產品:Mouse?IL-1β, IL-6 and TNF-α ELISA Kits ?
https://pubmed.ncbi.nlm.nih.gov/33118280/
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21.文章題目:MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264. 7 cell.
期 ???刊:Scientific reports(影響因子:3.998)
發(fā)表時間:27 October 2020
作 ???者:Xin Y, Yuan Q, Liu C, et al.
作者單位:三峽大學附屬仁和醫(yī)院
使用產品:Mouse TNF-α and IL-1β ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/33110183/
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22.文章題目:Suppression of lipopolysaccharide-induced activation of RAW 264.7 macrophages by Se-methylseleno-l-cysteine.
期 ???刊:International Immunopharmacology(影響因子:3.943)
發(fā)表時間:9 October 2020
作 ???者:Wang G, Zhan Q, Wu H.
作者單位:華南農業(yè)大學
使用產品:Mouse IL-1β, IL-6, IL-12p70 and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/pii/S156757692032600X
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23.文章題目:Glioma cells are resistant to inflammation?induced alterations of mitochondrial dynamics.
期 ???刊:International Journal of Oncology(影響因子:3.899)
發(fā)表時間:15 October 2020
作 ???者:Fan W, Song Y, Ren Z, et al.
作者單位:鄭州大學
使用產品:Human IL-6 ELISA Kit ??
https://www.spandidos-publications.com/10.3892/ijo.2020.5134
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24.文章題目:Chinese Medicine Huzhen Tongfeng Formula Effectively Attenuates Gouty Arthritis by Inhibiting Arachidonic Acid Metabolism and Inflammatory Mediators.
期 ???刊:Mediators of Inflammation(影響因子:3.758)
發(fā)表時間:09 October 2020
作 ???者:Deng J, Wu Z, Chen C, et al.
作者單位:廣東藥科大學
使用產品:Mouse IL-1β, IL-6 and?TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33132756/
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25.文章題目:Activation of murine RAW264.7 macrophages by oligopeptides from sea cucumber (Apostichopus japonicus) and its molecular mechanisms.
期 ???刊:Journal of Functional Foods(影響因子:3.701)
發(fā)表時間:19 October 2020
作 ???者:Cai N, Luo W, Yao L, et al.
作者單位:北京工商大學
使用產品:Mouse TNF-α and IL-6 ELISA Kits ??
https://www.sciencedirect.com/science/article/pii/S1756464620304539
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26.文章題目:Enhancement of nutritional soy protein and peptide supplementation on skin repair in rats.
期 ???刊:Journal of Functional Foods(影響因子:3.701)
發(fā)表時間:9 October 2020
作 ???者:Zhang J, Fu X, Li W, et al.
作者單位:北京工商大學
使用產品:Rat?IL-1β, TNF-α and IL-6 ELISA Kits ???
https://www.sciencedirect.com/science/article/pii/S1756464620304552
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27.文章題目:Sex differences in group 2 innate lymphoid cell-dominant allergic airway inflammation.
期 ???刊:Molecular Immunology(影響因子:3.641)
發(fā)表時間:20 October 2020
作 ???者:Wang C, Xu Z B, Peng Y Q, et al.
作者單位:中山大學第一附屬醫(yī)院
使用產品:Mouse IL-5 and IL-13 ELISA Kits
樣本類型:支氣管肺泡灌洗液
https://www.sciencedirect.com/science/article/pii/S0161589020304958
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28.文章題目:Ginsenoside Rb3 Inhibits Pro-Inflammatory Cytokines via MAPK/AKT/NF-κB Pathways and Attenuates Rat Alveolar Bone Resorption in Response to Porphyromonas gingivalis LPS.
期 ???刊:Molecules(影響因子:3.267)
發(fā)表時間:20 October 2020
作 ???者:Sun M, Ji Y, Li Z, et al.
作者單位:武漢大學口腔醫(yī)學院
使用產品:Human?IL-1β, IL-6 and?IL-8 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33092290/
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29.文章題目:The Chemical Composition of Brazilian Green Propolis and Its Protective Effects on Mouse Aortic Endothelial Cells against Inflammatory Injury.
期 ???刊:Molecules(影響因子:3.267)
發(fā)表時間:10 October 2020
作 ???者:Xu X, Yang B, Wang D, et al.
作者單位:福建農林大學
使用產品:Mouse IL-6 and TNF-α ELISA Kits ??????????
https://pubmed.ncbi.nlm.nih.gov/33050458/
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30.文章題目:S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway.
期 ???刊:Drug Design, Development and Therapy(影響因子:3.216)
發(fā)表時間:28 October 2020
作 ???者:Yang G, Sun S, Wang J, et al.
作者單位:山東第一醫(yī)科大學
使用產品:Rat IL-6 ELISA Kit
樣本類型:關節(jié)腔液 ???????
https://pubmed.ncbi.nlm.nih.gov/33149551/
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31.文章題目:Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and Central Tumor Necrosis Factor Alpha in Rats with Depression-Chronic Somatic Pain Comorbidity.
期 ???刊:Neural Plasticity(影響因子:3.093)
發(fā)表時間:22 October 2020
作 ???者:Guo X, Zhao Y, Huang F, et al.
作者單位:中國中醫(yī)科學院針灸研究所
使用產品:Rat TNF-α ELISA Kit ??
https://pubmed.ncbi.nlm.nih.gov/33144854/
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32.文章題目:Comprehensive analysis of circular RNAs from steatotic livers after ischemia and reperfusion injury by next-generation RNA sequencing.
期 ???刊:FEBS letters(影響因子:3.057)
發(fā)表時間:18 October 2020
作 ???者:Qu X, Zheng C, Wang B, et al.
作者單位:上海交通大學醫(yī)學院仁濟醫(yī)院
使用產品:Mouse IL-6 and TNF-α ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/33070312/
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33.文章題目:Comparison of toxicity of Ti3C2 and Nb2C Mxene quantum dots (QDs) to human umbilical vein endothelial cells.
期 ???刊:Journal of Applied Toxicology(影響因子:2.997)
發(fā)表時間:13 October 2020
作 ???者:Gu M, Dai Z, Yan X, et al.
作者單位:中國石油大學
使用產品:Human?IL-6 and IL-8?ELISA Kits??
https://pubmed.ncbi.nlm.nih.gov/33048420/
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34.文章題目:Abnormal cGMP-dependent protein kinase I-mediated decidualization in preeclampsia.
期 ???刊:Hypertension Research(影響因子:2.941)
發(fā)表時間:23 October 2020
作 ???者:Chen J, Ren W, Lin L, et al.
作者單位:廣州醫(yī)科大學附屬第三醫(yī)院
使用產品:Histostain-Plus IHC Kit
https://pubmed.ncbi.nlm.nih.gov/33093639/
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35.文章題目:LPS Enhances the Chemosensitivity of Oxaliplatin in HT29 Cells via GSDMD-Mediated Pyroptosis.
期 ???刊:Cancer Management and Research(影響因子:2.886)
發(fā)表時間:20 October 2020
作 ???者:Wu L S, Liu Y, Wang X, et al.
作者單位:河北醫(yī)科大學第四醫(yī)院
使用產品:Human IL-18 and IL-1β ELISA Kits ?????????
https://pubmed.ncbi.nlm.nih.gov/33116894/
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36.文章題目:IL-32 induces epithelial-mesenchymal transition by triggering endoplasmic reticulum stress in A549 cells.
期 ???刊:BMC Pulmonary Medicine(影響因子:2.813)
發(fā)表時間:23 October 2020
作 ???者:Gong L, Liu G, Zhu H, et al.
作者單位:暨南大學?
使用產品:Human TNF-α, TGF-β1, IL-1β and?IL-6 ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/33097029/
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37.文章題目:Protective Mechanism of MIF Inhibitor ISO-1 on Intrahepatic Bile Duct Cells in Rats with Severe Acute Pancreatitis.
期 ???刊:Digestive Diseases and Sciences(影響因子:2.751)
發(fā)表時間:29 October 2020
作 ???者:Wang B, Zhao K, Hu W, et al.
作者單位:武漢大學人民醫(yī)院
使用產品:Rat TNF-α, IL-1β and IL-6 ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/33123939/
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38.文章題目:Manganese exposure induces permeability in renal glomerular endothelial cells via the Smad2/3-Snail–VE-cadherin axis.
期 ???刊:Toxicology Research(影響因子:2.283)
發(fā)表時間:09 October 2020
作 ???者:Gao P, Tian Y, Xie Q, et al.
作者單位:山東省第一醫(yī)科大學附屬第一醫(yī)院千佛醫(yī)院
使用產品:Annexin V-FITC/PI apoptosis assay kit
https://academic.oup.com/toxres/advance-article-abstract/doi/10.1093/toxres/tfaa067/5906464
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39.文章題目:Comparison of two regimens for patients with thyroid?associated ophthalmopathy receiving intravenous methyl prednisolone: A single center prospective randomized trial.
期 ???刊:Experimental and Therapeutic Medicine(影響因子:1.785)
發(fā)表時間:6 October 2020
作 ???者:Mu P W, Tang X X, Wang Y N, et al.
作者單位:中山大學附屬第三醫(yī)院
使用產品:Human?IL-2, IL-6 and IL-17 ELISA Kits??
https://pubmed.ncbi.nlm.nih.gov/33093891/
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40.文章題目:Effects of different diet?induced postnatal catch?up growth on glycolipid metabolism in intrauterine growth retardation male rats.
期 ???刊:Experimental and Therapeutic Medicine(影響因子:1.785)
發(fā)表時間:2 October 2020
作 ???者:Wu Y, Yin G, Wang P, et al.
作者單位:汕頭大學醫(yī)學院
使用產品:Rat MCP-1 and TNF-α ELISA Kits???
https://pubmed.ncbi.nlm.nih.gov/33082866/
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